Pediatric Neurology

Prenatal Folic Acid Fortification May Affect Cortical Development

Prenatal Folic Acid Fortification May Affect Cortical Development

Gestational exposure to folic acid fortification is associated with cortical development.

Increased Multigenerational ADHD Risk Linked to DES Exposure During Pregnancy

Increased Multigenerational ADHD Risk Linked to DES Exposure During Pregnancy

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Investigators sought to investigate the association between the use of diethylstilbestrol during pregnancy on risk for ADHD in subsequent generations.

In Children, Food Insecurity Tied to Behavior, Cognition

In Children, Food Insecurity Tied to Behavior, Cognition

Food insecurity may be linked to behavioral problems and poorer cognitive performance in children.

Early Preterm Birth Linked to Increased ADHD Symptoms

Early Preterm Birth Linked to Increased ADHD Symptoms

Early preterm birth is associated with a higher level of ADHD symptoms in preschool children.

NEURO Study: Neonatal neuroimaging with strong negative predictive value for developmental outcomes

In multivariate analyses, adverse late cranial ultrasound findings were an independent risk factor for full scale IQ scores.

Prenatal antidepressant exposure may increase risk of poor motor development

A meta-analysis of 18 studies examining the association of prenatal antidepressant exposure with motor development in children showed a small overall effect of worse motor development outcomes among children exposed to antidepressants in pregnancy.

Child Neuroblastoma Survivors at Risk for Psych Impairment

Child Neuroblastoma Survivors at Risk for Psych Impairment

Neuroblastoma survivors are at elevated risk for psychological impairment.

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

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Since MRI and EEG risk factors were retrospectively reviewed, the study was unable to analyze the temporal seizure burden or the volume of MRI injury, both of which may have provided greater insights into outcomes.

No Benefit for Measuring Closing Pressure in Pediatric Pseudotumor Cerebri Syndrome

No Benefit for Measuring Closing Pressure in Pediatric Pseudotumor Cerebri Syndrome

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No significant association among closing pressure, amount of CSF removed, and time to resolution of papilledema is reported in patients with PTCS.

Knowledge Gaps Found for Non-Drug Therapy in Peds ADHD

Knowledge Gaps Found for Non-Drug Therapy in Peds ADHD

There are considerable gaps in knowledge relating to the effectiveness of non-pharmacologic treatments for ADHD in pediatric patients.

Associations Between Maternal Depression, Support, and Cognitive Development in Offspring

Associations Between Maternal Depression, Support, and Cognitive Development in Offspring

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A study evaluated the long-term adverse effects of maternal depression on child development.

Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

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The Agency has received reports of serious neural tube birth defects involving the brain, spine, and spinal cord in babies born to women who received dolutegravir for HIV treatment.

Congenital Heart Disease, Hispanic Ethnicity Associated With Increased Mortality in Pediatric Arterial Ischemic Stroke

Congenital Heart Disease, Hispanic Ethnicity Associated With Increased Mortality in Pediatric Arterial Ischemic Stroke

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The investigators were unable to determine which type of congenital heart disease or which type of ventricular assist device, if used, played a role in mortality outcomes.

Unmet Therapy Needs Common in Children With Traumatic Brain Injury

Unmet Therapy Needs Common in Children With Traumatic Brain Injury

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Children hospitalized for traumatic brain injury tend to have unmet needs for educational and rehabilitation services approximately 2 years after a traumatic brain injury event.

Peripheral Neuropathy Common in Childhood Cancer Survivors

Peripheral Neuropathy Common in Childhood Cancer Survivors

Childhood cancer survivors frequently have clinical abnormalities attributable to peripheral neuropathy.

Executive Function Improved With Prenatal Exposure to SSRIs

Executive Function Improved With Prenatal Exposure to SSRIs

Children with prenatal exposure to serotonin reuptake inhibitors have better executive function at age 12 years.

FDA Approves First Multiple Sclerosis Treatment for Pediatric Patients

FDA Approves First Multiple Sclerosis Treatment for Pediatric Patients

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The FDA's decision was based on data from the Phase 3 PARADIGMS study (N=215) which evaluated the safety and efficacy of oral fingolimod vs interferon beta-1a injection in pediatric patients aged 10 to <18 years with relapsing MS.

Maternal, Child Sugar Intake Could Impact Child Cognition

Maternal, Child Sugar Intake Could Impact Child Cognition

Greater sugar consumption during pregnancy and early childhood may adversely impact child cognition.

Dimethyl Fumarate May Be Safe, Effective for Pediatric Multiple Sclerosis

Dimethyl Fumarate May Be Safe, Effective for Pediatric Multiple Sclerosis

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Previous studies have shown that delayed-release DMF is safe and effective in treating RRMS in adult patients. The goal of this study was to extend these analyses to evaluate DMF in pediatric patients with RRMS.

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With Cytomegalovirus Infections

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With Cytomegalovirus Infections

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Investigators retrospectively reviewed the patients' medical records and MRI images and assessed the associations between the MRI findings and neurologic outcomes, specifically neurodevelopmental achievement, epilepsy, and sensorineural hearing loss.

IV Methylprednisolone Reduces Duration of Kleine-Levin Syndrome Episodes

IV Methylprednisolone Reduces Duration of Kleine-Levin Syndrome Episodes

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A team of investigators assessed the effect of intravenous administration of methylprednisolone on duration of episodes in adolescent and young adult patients with Kleine-Levin syndrome.

Adjunctive Eslicarbazepine Safe and Well Tolerated for Pediatric Seizures

Adjunctive Eslicarbazepine Safe and Well Tolerated for Pediatric Seizures

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Researchers conducted post-hoc analysis of data derived from 2 randomized, placebo-controlled trials to determine the safety and tolerability of eslicarbazepine in pediatric patients with partial-onset seizures not responsive to treatment with ≤2 antiepileptic drugs.

Caffeine Therapy for Apnea of Prematurity Safe Over Long Term

Caffeine Therapy for Apnea of Prematurity Safe Over Long Term

Neonatal caffeine therapy for apnea of prematurity has no detrimental long-term effects and even improves some neurologic measures.

Extremely preterm children more likely to develop motor impairment

This prospective cohort study showed that children born extremely premature or at an extremely low birth weight were more likely to develop cerebral palsy or non-CP motor impairment at 8 years' corrected age when compared to matched controls born at term.

Isolated vomiting not linked to clinically important TBI in children

Isolated vomiting was not associated with clinically important TBI or evidence of TBI on computed tomography scans among pediatric patients with head injury.

Psychosis Could Be a Potential Side Effect of Steroid Treatment in Kids

Psychosis Could Be a Potential Side Effect of Steroid Treatment in Kids

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Iatrogenic steroid-induced psychosis is a rare side effect of glucocorticoid therapy which is mostly seen in adults, although it has been reported in children and adolescents.

Prenatal Exposure to SSRI Tied to Fetal Brain Development

Prenatal Exposure to SSRI Tied to Fetal Brain Development

Prenatal exposure to a selective serotonin reuptake inhibitor is associated with fetal brain development.

White Matter Tracts Differ for Infants With Fragile X Syndrome

White Matter Tracts Differ for Infants With Fragile X Syndrome

There are significant differences in the development of 12 fiber tracts between infants with fragile X syndrome and controls.

Early-Life Epilepsy Should Be Urgently Treated With EBM

Early-Life Epilepsy Should Be Urgently Treated With EBM

Best diagnostics and evidence-based treatments should be used from the start of the disease.

Early Infection With Zika Virus Associated With More Birth Defects in Pregnancy

Early Infection With Zika Virus Associated With More Birth Defects in Pregnancy

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Among pregnant women with Zika virus infection, birth defects were reported more often in fetuses and infants whose mothers had been infected with the virus early in their pregnancies.

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