Promethazine HCl Rectal Suppositories Rx
Generic Name and Formulations:
Promethazine HCl 12.5mg, 25mg, 50mg.
Various generic manufacturers
Indications for Promethazine HCl Rectal Suppositories:
Motion sickness. Perioperative nausea & vomiting.
Motion sickness: 25mg 30–60mins before travel; may repeat in 8–12hrs; maintenance 25mg twice daily. Perioperative nausea & vomiting: 25mg; may give additional doses of 12.5–25mg at 4–6hr intervals.
<2yrs: see Contraindications. Motion sickness: ≥2yrs: 12.5–25mg twice daily. Perioperative nausea & vomiting: 0.5mg/lb or 25mg; may give additional doses of 12.5–25mg or 0.5mg/lb at 4–6hr intervals.
Children <2yrs. Dehydrated or ill children (esp. Reye's syndrome). History of sleep apnea. Asthma and lower respiratory disorders. Uncomplicated nausea in children.
Glaucoma. GI or urinary obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Children ≥2yrs. Pregnancy (Cat.C). Nursing mothers: not recommended.
Potentiates CNS depression with alcohol, other CNS depressants. Caution with MAOIs. May alter hCG pregnancy test results.
Drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, neonatal platelet abnormalities; children: respiratory depression (may be fatal).
Formerly known under the brand names Phenergan (tabs, supps); Promethacon (supps).
Neurology Advisor Articles
- High-Dose Biotin May Be an Effective Treatment for Progressive MS
- Biobank Data Suggest Vitamin D Reduces Risk for Multiple Sclerosis
- Patients With Multiple Sclerosis Face Greater Infection Risk
- Fingolimod Compared With Glatiramer Acetate in Head-to-Head MS Study
- Lower Relapse Risk and Disability Progression With Oral DMT in Treatment-Naive RRMS
- High Frequency of Headaches Following Dialysis Associated With BUN and Blood Pressure
- OnabotulinumtoxinA Injections Reduce Frequency of Cluster Headaches
- Aetna-CVS Merger Approved
- Trump to Sign Bills Lifting Drug Price 'Gag Orders' on Pharmacists
- Pediatric Migraine: Evidence-Based Alternative Management