Psychosis

Pimavanserin Confers Greater Improvements in Alzheimer Disease Psychosis vs Placebo

Pimavanserin Confers Greater Improvements in Alzheimer Disease Psychosis vs Placebo

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Pimavanserin is currently approved in the United States for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis.

Memantine Plus Cholinesterase Inhibitors Improves Psychosis, Neurobehavioral Symptoms in Alzheimer Disease

Memantine Plus Cholinesterase Inhibitors Improves Psychosis, Neurobehavioral Symptoms in Alzheimer Disease

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Investigators pooled data from patients from 3 phase 3, 24-week, randomized, placebo-controlled trials of MEM in patients with Alzheimer disease receiving concurrent ChEIs.

Cannabis Use Linked to Psychosis Symptoms in Adolescents

Cannabis Use Linked to Psychosis Symptoms in Adolescents

Cannabis use is associated with psychosis symptoms during adolescence.

Short-Term Benefit for Alzheimer Disease Psychosis With Pimavanserin

Short-Term Benefit for Alzheimer Disease Psychosis With Pimavanserin

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Despite its short-term efficacy, pimavanserin provided no significant benefit in the overall cohort for improving psychotic symptoms at 12 weeks of treatment when compared with placebo.

Alzheimer's Not Linked to a History of Psychiatric Disorders

Alzheimer's Not Linked to a History of Psychiatric Disorders

Patients previously diagnosed with depression or anxiety did not have a greater risk of Alzheimer's.

Alzheimer's Related Gene May Induce Psychosis in Females

Alzheimer's Related Gene May Induce Psychosis in Females

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Females with Alzheimer's disease, the APOE4 gene, and comorbid Lewy bodies were more likely to experience psychosis.

Acute Stroke Risk Elevated in Patients With Psychiatric Illness

Acute Stroke Risk Elevated in Patients With Psychiatric Illness

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Psychological distress may cause changes within cells that trigger inflammation and oxidative stress, both of which are believed to increase stroke risk.

Significant Cognitive Defects in Those At High Risk of Psychosis

Significant Cognitive Defects in Those At High Risk of Psychosis

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Studying cognition deficits during the clinical high risk period allows researchers to look at changes in the near psychotic state before chronicity and long-term medication use obscure the core deficits.

Characteristics Associated With Antiepileptic Drug-Induced Psychotic Disorders

Characteristics Associated With Antiepileptic Drug-Induced Psychotic Disorders

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Patients taking levetiracetam should be monitored for AIPD.

New Risk Calculator Helps Predict Conversion to Psychosis in High-Risk Patients

New Risk Calculator Helps Predict Conversion to Psychosis in High-Risk Patients

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The calculator is available freely online for use by clinicians.

CSF Biomarkers Aid in Psychiatric, Cognitive Disorders Differential Diagnosis

CSF Biomarkers Aid in Psychiatric, Cognitive Disorders Differential Diagnosis

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This is the first study to examine the role of CSF biomarkers in the diagnosis of patients with cognitive symptoms and psychiatric disorders in routine daily clinical practice.

FDA Approves Nuplazid for Parkinson's Disease Psychosis

FDA Approves Nuplazid for Parkinson's Disease Psychosis

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The drug is the first of its kind to address PD psychosis without having an ill effect on motor symptoms.

FDA Panel Warily Votes In Favor of Novel Parkinson's Psychosis Drug

FDA Panel Warily Votes In Favor of Novel Parkinson's Psychosis Drug

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The need for an effective treatment appeared to sway panelists who expressed reservations about the safety and efficacy of pimavanserin.

Biotypes Highlight Unique Biological Manifestations of Psychosis

Biotypes Highlight Unique Biological Manifestations of Psychosis

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The unique biotypes may allow for more targeted treatments to be developed.

Nuplazid for Parkinson's Psychosis Set for Priority Review by FDA

Nuplazid for Parkinson's Psychosis Set for Priority Review by FDA

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If approved, Nuplazid will be the first treatment specifically designed to address PDP.

Preexisting Conditions Can Complicate Concussion Diagnosis

Preexisting Conditions Can Complicate Concussion Diagnosis

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Girls with a history of a psychiatric condition, substance abuse, or ADHD were more likely to report concussion-like symptoms.

fMRI May Help Identify Correct Schizophrenia Treatment

fMRI May Help Identify Correct Schizophrenia Treatment

The personalized approach to treatment could help prevent trial-and-error periods.

FDA Approves Vraylar for Bipolar Disorder, Schizophrenia

FDA Approves Vraylar for Bipolar Disorder, Schizophrenia

The FDA's approval was based on data from controlled trials in adults with manic or mixed episodes of bipolar I disorder and schizophrenia.

Antipsychotics May Contribute to Gray Matter Loss in Schizophrenia

Antipsychotics May Contribute to Gray Matter Loss in Schizophrenia

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Second-generation antipsychotics appear to have a neuroprotective effect on the brain.

Acadia Submits Nuplazid NDA for Psychosis in Parkinson's

Acadia Submits Nuplazid NDA for Psychosis in Parkinson's

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If approved, Nuplazid will be the first drug approved to treat psychosis in Parkinson's disease.

Treatment Challenges in Parkinson's Disease Psychosis

Treatment Challenges in Parkinson's Disease Psychosis

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Parkinson's disease psychosis is underreported and is difficult to treat, but a new drug in late-stage development is a promising therapy.

Speech Analysis Tool May Help Identify Psychosis

Speech Analysis Tool May Help Identify Psychosis

Automated speech analysis more accurately classified at-risk young people than clinical ratings.

Omega-3 Supplement May Help Stave Off Schizophrenia

Omega-3 Supplement May Help Stave Off Schizophrenia

A three-month course of daily omega-3 supplements prevented the progression to a psychotic disorder in the majority of participants.

Patients with Psychosis Show Prominent Thalamic Dysconnectivity

Patients with Psychosis Show Prominent Thalamic Dysconnectivity

Those who converted to full illness showed pronounced thalamic dysconnectivity.

Opioid, Sedative Co-Prescribing Rates Still High

Opioid, Sedative Co-Prescribing Rates Still High

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Despite guidelines that advise against co-prescribing of opioids and sedative hypnotics, rates did not decrease over a nine-year period.

Most Dementia Patients Prescribed Multiple Psychotropic Drugs

Most Dementia Patients Prescribed Multiple Psychotropic Drugs

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Younger, female patients were most associated with psychotropic polypharmacy.

Cognitive Behavioral Therapy Effective for Insomnia in Mental Illness

Cognitive Behavioral Therapy Effective for Insomnia in Mental Illness

Patients with psychiatric disorders who received CBT for insomnia saw symptom of both conditions improve.

Antipsychotics Increase Mortality in Parkinson's Disease

Antipsychotics Increase Mortality in Parkinson's Disease

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Antipsychotics significantly increase mortality rates for patients with Parkinson's disease.

Pediatric Mental Health Treatment Increasing for Less Severe Symptoms

Pediatric Mental Health Treatment Increasing for Less Severe Symptoms

Most of the increase has been among patients who have less serious illness.

Depression, Bipolar Disorder Linked to Reduced Brain Connectivity

Depression, Bipolar Disorder Linked to Reduced Brain Connectivity

MRI showed reduced connectivity in the right posterior parietal cortex in women with depression or bipolar disorder.

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