Seizure Disorders

Does Gestational Age at Birth Affect Seizure Risk After Measles Vaccine Administration?

Does Gestational Age at Birth Affect Seizure Risk After Measles Vaccine Administration?

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The study utilized the Vaccine Safety Datalink and included children who received the first dose of a measles-containing vaccine between 12 and 23 months old during the study period of January 1, 2003 to September 20, 2015.

Bilateral Independent Periodic Discharges and Poor Seizure Outcomes

Bilateral Independent Periodic Discharges and Poor Seizure Outcomes

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Investigators assessed the frequency of bilateral independent periodic discharges in patients experiencing electrographic seizures and their effect on patient mortality and clinical outcomes.

Eslicarbazepine Acetate Well Tolerated, Effective in Post-Stroke Epilepsy

Eslicarbazepine Acetate Well Tolerated, Effective in Post-Stroke Epilepsy

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Eslicarbazepine acetate is well tolerated and may be effective for treating patients with post-stroke epilepsy.

Long-Term Effectiveness of Adjunctive Brivaracetam For Previously Treated Focal Seizures

Long-Term Effectiveness of Adjunctive Brivaracetam For Previously Treated Focal Seizures

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Adjunctive brivaracetam may provide long term effectiveness in adults who have not seen optimal results with other common treatments.

Fenfluramine Improves Emotion and Behavior Regulation in Pediatric Dravet Syndrome

Fenfluramine Improves Emotion and Behavior Regulation in Pediatric Dravet Syndrome

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Children with Dravet syndrome receiving fenfluramine experienced improvements in emotional regulation, behavioral regulation, and planning and organization abilities.

Psychiatric Adverse Effects from Levetiracetam Linked to Certain Factors

Psychiatric Adverse Effects from Levetiracetam Linked to Certain Factors

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Researchers aimed to identify risk factors associated with a psychiatric event following a first prescription for levetiracetam.

SSRIs, TCAs, Antipsychotics Decrease Seizure Frequency in the Epilepsy Monitoring Unit

SSRIs, TCAs, Antipsychotics Decrease Seizure Frequency in the Epilepsy Monitoring Unit

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Patients taking an active treatment regimen consisting of SSRIs, TCAs, or antipsychotic medications are less likely to experience a seizure in the epilepsy monitoring unit.

Positive Retention Rates and Sustained Efficacy With Perampanel in Epilepsy

Positive Retention Rates and Sustained Efficacy With Perampanel in Epilepsy

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Perampanel at a median maximum dose of 6 mg (1 to 20 mg) is associated with good long-term treatment retention and sustained efficacy.

Enzyme-Inducing Antiepileptic Drugs Increase Vitamin D Requirements in Epilepsy

Enzyme-Inducing Antiepileptic Drugs Increase Vitamin D Requirements in Epilepsy

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Investigators aimed to determine whether utilization of enzyme-inducing antiepileptic drugs increases vitamin D requirements.

Does Total Benzodiazepine Dose Affect Pediatric ICU Duration for Status Epilepticus?

Does Total Benzodiazepine Dose Affect Pediatric ICU Duration for Status Epilepticus?

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Low total benzodiazepine dosing is linked to longer intensive care unit stays and seizure duration in children.

Risk of Sudden Unexplained Death in Epilepsy May Wane Over Time

Risk of Sudden Unexplained Death in Epilepsy May Wane Over Time

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Patients at high risk for SUDEP may shift to a lower risk group over time.

Tolerance to Cannabidiol for Treatment-Resistant Epilepsy Seen Over Time

Tolerance to Cannabidiol for Treatment-Resistant Epilepsy Seen Over Time

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Tolerance to cannabidiol may exist, potentially limiting its efficacy as an antiseizure therapy in the long-term management of epilepsy.

Migraine Comorbidity May Increase Depression Risk in Patients With Focal Epilepsy

Migraine Comorbidity May Increase Depression Risk in Patients With Focal Epilepsy

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Patients with focal epilepsy and comorbid migraine may have greater depressive symptoms compared with individuals without the comorbidity.

DRESS May Be Mitigated by Slower Titration Rates of Cenobamate

DRESS May Be Mitigated by Slower Titration Rates of Cenobamate

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Investigators examined whether a reduction in titration rates utilized in earlier trials would reduce the incidence of DRESS in patients taking cenobamate.

Efficacy, Safety of Eslicarbazepine Acetate in Elderly Patients Examined

Efficacy, Safety of Eslicarbazepine Acetate in Elderly Patients Examined

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Safety and efficacy were examined in adults aged 60 compared with adults younger than 60.

Adverse Reactions Increase Risk for Further Drug Intolerability in Epilepsy

Adverse Reactions Increase Risk for Further Drug Intolerability in Epilepsy

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Antiepileptic drugs are more likely to be tolerated by patients who have not experienced adverse drug reactions to previous antiepileptic drugs.

Long-Term Safety of Midazolam Nasal Spray for Acute Repetitive Seizures

Long-Term Safety of Midazolam Nasal Spray for Acute Repetitive Seizures

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Midazolam nasal spray, a novel benzodiazepine formulation, may be a safe, long-term treatment option for acute seizure episodes.

Perampanel Add-On Therapy Effectively Treats Focal and Generalized Epilepsy

Perampanel Add-On Therapy Effectively Treats Focal and Generalized Epilepsy

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In the retrospective study, the primary reason for initiating perampanel was poor seizure control.

Oral Film Formulation of Clobazam Gets FDA Approval for LGS

Oral Film Formulation of Clobazam Gets FDA Approval for LGS

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Aquestive Therapeutics announced that the FDA has approved Sympazan oral film as adjunctive treatment of seizures associated with LGS in patients aged ≥2 years old.

Circadian, Circaseptan Rhythms Prevalent in Epileptic Seizure Cycles

Circadian, Circaseptan Rhythms Prevalent in Epileptic Seizure Cycles

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Researchers used analytic techniques from circular statistics to quantify the prevalence, frequency, and strength of seizure cycles in patients with epilepsy.

Resective Epilepsy Surgery Reduces Seizures, Improves Social Functioning in Lennox-Gastaut Syndrome

Resective Epilepsy Surgery Reduces Seizures, Improves Social Functioning in Lennox-Gastaut Syndrome

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Better social competence and adaptive behavior was achieved by seizure-free patients at post-surgery follow-ups compared with patients with persistent seizures (P <.05).

Epidiolex Now Available to Treat Seizures Associated With LGS, Dravet Syndrome

Epidiolex Now Available to Treat Seizures Associated With LGS, Dravet Syndrome

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The Food and Drug Administration (FDA) approved the treatment in June 2018, making it the first prescription pharmaceutical formulation of highly-purified, plant-derived cannabidiol, as well as the first treatment indicated for patients with Dravet syndrome.

Predictors for Epilepsy Following Acute Symptomatic Neonatal Seizures Remain Elusive

Predictors for Epilepsy Following Acute Symptomatic Neonatal Seizures Remain Elusive

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The researchers sought to identify risk factors for seizures in this population by reviewing hospital records.

High-Frequency Oscillations Not a Good Predictor of Outcomes After Epilepsy Surgery

High-Frequency Oscillations Not a Good Predictor of Outcomes After Epilepsy Surgery

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HFOs were predictors of good or poor surgical outcome in 69.2% of patients, resulting in a modest validation of the researchers' hypothesis.

Unintended Pregnancy Common in Women With Epilepsy

Unintended Pregnancy Common in Women With Epilepsy

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It is likely that both maternal age and socioeconomic status contribute to the higher rates of pregnancy in WWE compared with women without epilepsy.

Managing Status Epilepticus in Palliative Care: Accounting for Patient and Family Experience

Managing Status Epilepticus in Palliative Care: Accounting for Patient and Family Experience

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There are considerations for treating these seizures as part of the overall goals of palliative care, which include the family's experience.

Acetaminophen reduces recurrence of febrile seizures in children within same fever episode

Rectal acetaminophen reduces rates of second febrile seizure in children during the course of the same febrile illness when given rectally soon after initial seizure.

Fycompa Approved for Younger Epilepsy Patients With Partial-Onset Seizures

Fycompa Approved for Younger Epilepsy Patients With Partial-Onset Seizures

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Safety data for Fycompa was consistent with the safety profile in adult populations without the need for weight-based dosing.

DEA Reschedules Marijuana-Based Drug Epidiolex

DEA Reschedules Marijuana-Based Drug Epidiolex

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Drugs with a Schedule V classification have proven medical use and low abuse potential.

NDA Submitted for Valtoco Nasal Spray to Treat Acute Repetitive Seizures

NDA Submitted for Valtoco Nasal Spray to Treat Acute Repetitive Seizures

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The Company states that the NDA is supported by robust clinical trial data, including patients studies where more than 1600 seizures were treated with Valtoco nasal spray.

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