Seizures

Valproic Acid-Related Adverse Fetal Outcomes May Be Linked to Placental Effects

Valproic Acid-Related Adverse Fetal Outcomes May Be Linked to Placental Effects

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The effects of short-term VPA exposure on placental compound carrier expression were examined in this study.

Low Income, Singlehood, and Race Tied to Seizure Control in Active Epilepsy

Low Income, Singlehood, and Race Tied to Seizure Control in Active Epilepsy

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A majority of participants (67%) had reported seeing a neurologist or epilepsy specialist in the past year, with younger adults comprising a higher percentage of these participants.

Briviact Approved for Pediatric Patients With Partial-Onset Seizures

Briviact Approved for Pediatric Patients With Partial-Onset Seizures

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The expanded approval was supported by extrapolated efficacy data from placebo-controlled studies in adults with partial-onset seizures.

Factors Associated With Treatment Delays in Pediatric Refractory Status Epilepticus

Factors Associated With Treatment Delays in Pediatric Refractory Status Epilepticus

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The investigators concluded that these findings should help to identify targets for intervention to reduce the overall time to treatment in this population.

Lyrica Approved as Adjunctive Tx for Partial Onset Seizures in Children

Lyrica Approved as Adjunctive Tx for Partial Onset Seizures in Children

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The approval was based on a 12-week, double-blind, placebo-controlled study (N=295) in pediatric patients 4-17 years of age.

FDA Approves Deep Brain Stimulation Therapy for Refractory Epilepsy

FDA Approves Deep Brain Stimulation Therapy for Refractory Epilepsy

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The approval is specifically for bilateral anterior thalamic nucleus stimulation and is based on results from the SANTE study (Stimulation of the Anterior Nucleus of the Thalamus in Epilepsy).

Too Few Adults Taking Epilepsy Medications Have Seizure Control

Too Few Adults Taking Epilepsy Medications Have Seizure Control

Although most adults with epilepsy report taking epilepsy medication, less than half of those report having their seizures controlled.

Rate of Carbamazepine-Induced Cutaneous Adverse Reactions Reduced With Genetic Screening

Rate of Carbamazepine-Induced Cutaneous Adverse Reactions Reduced With Genetic Screening

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Researchers evaluated the use of genetic screening to identify individuals who are at risk for carbamazepine-induced cutaneous adverse drug reactions.

Suicidal Behavior Increased With Opioids, Psychotropic Medication Misuse in Epilepsy

Suicidal Behavior Increased With Opioids, Psychotropic Medication Misuse in Epilepsy

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Investigators conducted a population-based study to assess risk and cause of unnatural mortality in individuals with epilepsy.

FDA: Lamotrigine Linked to Potentially Life-Threatening Adverse Reaction

FDA: Lamotrigine Linked to Potentially Life-Threatening Adverse Reaction

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Clinicians should conduct a medical evaluation as soon as suspicious symptoms are reported and discontinue lamotrigine if HLH is suspected.

Treatment-Emergent Adverse Events With Adjunctive Eslicarbazepine Acetate in Pediatric Epilepsy

Treatment-Emergent Adverse Events With Adjunctive Eslicarbazepine Acetate in Pediatric Epilepsy

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Researchers evaluated the incidence of treatment-emergent adverse events in pediatric patients taking eslicarbazepine acetate with other antiepileptic drugs to better understand tolerability profiles.

Adjunctive Eslicarbazepine Safe and Well Tolerated for Pediatric Seizures

Adjunctive Eslicarbazepine Safe and Well Tolerated for Pediatric Seizures

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Researchers conducted post-hoc analysis of data derived from 2 randomized, placebo-controlled trials to determine the safety and tolerability of eslicarbazepine in pediatric patients with partial-onset seizures not responsive to treatment with ≤2 antiepileptic drugs.

Seizure-Free Status Prior to Conception Lowers Odds of Recurrence During Pregnancy

Seizure-Free Status Prior to Conception Lowers Odds of Recurrence During Pregnancy

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Prior studies have suggested that women with epilepsy who are seizure free ≥9 months prior to pregnancy have a high likelihood of remaining seizure free during pregnancy.

Listening to Sonified EEG Fluctuations May Help Identify Silent Seizures

Listening to Sonified EEG Fluctuations May Help Identify Silent Seizures

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In the event where electroencephalograms featured either seizures or seizure-like patterns, nonexpert medical students who auditorily reviewed the electroencephalograms rated samples as seizures with a higher degree of specificity vs experts or nonexpert medical students.

Add-On Cannabidiol for Treatment-Resistant Drop Seizures in Lennox-Gastaut Syndrome

Add-On Cannabidiol for Treatment-Resistant Drop Seizures in Lennox-Gastaut Syndrome

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Cannabidiol may be effective as add-on treatment for drop seizures associated with Lennox-Gastaut syndrome.

Afinitor Disperz Approved to Treat TSC-Associated Partial-Onset Seizures

Afinitor Disperz Approved to Treat TSC-Associated Partial-Onset Seizures

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The FDA has approved Afinitor Disperz for the adjunctive treatment of patients aged ≥2 years with TSC-associated partial-onset seizures.

Increased Risk of Unnatural Death in People With Epilepsy

Increased Risk of Unnatural Death in People With Epilepsy

The risk of unnatural death is increased among people with epilepsy.

Cannabidiol Safe, Well Tolerated in Children With Dravet Syndrome

Cannabidiol Safe, Well Tolerated in Children With Dravet Syndrome

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Because of the small size of the study sample, the findings may be limited to this patient population and may be hard to generalize across all pediatric patients with Dravet syndrome.

EEG Changes in Pediatric BECTS Promoted by Treatment With Levetiracetam, Sulthiame

EEG Changes in Pediatric BECTS Promoted by Treatment With Levetiracetam, Sulthiame

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The small sample size included in the study precludes the ability to make generalized statements about electroencephalogram pattern characteristics in the entire pediatric patient population with BECTS.

Early-Life Epilepsy Should Be Urgently Treated With EBM

Early-Life Epilepsy Should Be Urgently Treated With EBM

Best diagnostics and evidence-based treatments should be used from the start of the disease.

Educational Attainment Down With In Utero Exposure to AEDs

Educational Attainment Down With In Utero Exposure to AEDs

Exposure to sodium valproate or a combination of antiepileptic drugs in utero is associated with worse attainment on national educational tests.

Fycompa sNDA Submitted for Pediatric Seizure Indications

Fycompa sNDA Submitted for Pediatric Seizure Indications

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The proposed pediatric indications are based on a 2018 Draft Guidance that supports extrapolating efficacy data of approved drugs to treat POS in adults to pediatric patients aged ≥4 years.

Code Stroke System Reduces Post-Stroke Epilepsy Risk in Older Adults

Code Stroke System Reduces Post-Stroke Epilepsy Risk in Older Adults

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The adjusted analysis also demonstrated that the code stroke system was associated with a decreased risk for post-stroke epilepsy within 5 years of stroke.

Epilepsy Associated With Greater Risk for Serious Transportation Accidents

Epilepsy Associated With Greater Risk for Serious Transportation Accidents

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The registers used in this study did not collect information on whether individuals with epilepsy were actually responsible for the transportation accidents.

A Convenient Truth: The Problem With Seizure Under-Reporting and How to Fix It

A Convenient Truth: The Problem With Seizure Under-Reporting and How to Fix It

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Before we begin to rely more heavily on technology for seizure detection, clinician-patient trust needs to improve.

Cannabinoids May Be Effective as Adjunctive Treatment for Refractory Epilepsy

Cannabinoids May Be Effective as Adjunctive Treatment for Refractory Epilepsy

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Pharmaceutical-grade CBD used as adjunctive therapy in patients with pediatric-onset drug-resistant epilepsy may reduce the frequency of seizures.

Older Epilepsy Patients More Likely to Experience AED, Non-AED Drug Interaction

Older Epilepsy Patients More Likely to Experience AED, Non-AED Drug Interaction

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The findings are limited to the 50 most-prescribed non-epilepsy drugs assessed in this Medicare population and may not generalize to non-Medicare beneficiaries who receive other non-epilepsy drugs.

More Evidence Supports Benefits of Cannabidiol for Treatment-Resistant Epilepsy

More Evidence Supports Benefits of Cannabidiol for Treatment-Resistant Epilepsy

Cannabinoids are effective as an adjunctive treatment for reducing seizure frequency in pediatric-onset treatment-resistant epilepsy.

Predicting Seizure Risk Following Ischemic Stroke With SeLECT Score

Predicting Seizure Risk Following Ischemic Stroke With SeLECT Score

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Investigators sought to validate a tool to identify post-stroke seizure risk.

Behavioral Interventions May Have Some Benefit in Refractory Epilepsy

Behavioral Interventions May Have Some Benefit in Refractory Epilepsy

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Participants in the progressive muscle relaxation group reported greater reductions in stress vs those randomized to the focused-attention activity.

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