Seizures

Significant Variations in Epilepsy Surgical Strategy, Deficit Reporting Exist

Significant Variations in Epilepsy Surgical Strategy, Deficit Reporting Exist

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This widespread variation in strategies may contribute to undesirable outcomes that are characterized by poor seizure control and added deficits.

Brivaracetam Effective for Reducing Seizures in Patients with Epileptic Encephalopathies

Brivaracetam Effective for Reducing Seizures in Patients with Epileptic Encephalopathies

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Although 2 patients experienced an increase in seizure frequency, the remaining patients did not experience a change in frequency.

Add-On Cannabidiol Reduces Seizure Frequency in Treatment-Refractory Epilepsy

Add-On Cannabidiol Reduces Seizure Frequency in Treatment-Refractory Epilepsy

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Countable seizure types were recorded in parents' and caregivers' clinical diaries during a 4-week baseline period.

Clinical Factors Influencing Neuroimaging Yield in Nonindex Seizures Identified

Clinical Factors Influencing Neuroimaging Yield in Nonindex Seizures Identified

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The investigators sought to detect whether neuroimaging during an emergency department visit was associated with acute changes in the management of patients.

Late-Onset Epilepsy Linked to <i>APOE</i> ε4, Smoking, Diabetes

Late-Onset Epilepsy Linked to APOE ε4, Smoking, Diabetes

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The risk for late-onset epilepsy was lower in patients with higher physical activity levels and moderate alcohol intake.

Outcomes After Seizure Recurrence Upon AED Withdrawal Following Temporal Lobectomy

Outcomes After Seizure Recurrence Upon AED Withdrawal Following Temporal Lobectomy

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Recurrence of seizures was reported in 28.2% of patients who attempted withdrawal.

Sympazan Oral Film Granted Tentative Approval for Lennox-Gastaut Syndrome

Sympazan Oral Film Granted Tentative Approval for Lennox-Gastaut Syndrome

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Clobazam is currently available as oral tablets and suspension under the trade name Onfi (Lundbeck).

Anticonvulsants Not Associated With Risk for Perinatal Bleeding

Anticonvulsants Not Associated With Risk for Perinatal Bleeding

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The findings offer some reassurance for clinicians and for pregnant women who are successfully treated with enzyme-inducing ACDs.

Diacomit Approved for the Treatment of Dravet Sydrome

Diacomit Approved for the Treatment of Dravet Sydrome

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Diacomit was evaluated in 2 multicenter, placebo-controlled, double-blind, randomized studies.

Early Treatment Failure More Likely With Carbamazepine vs Lamotrigine in Epilepsy

Early Treatment Failure More Likely With Carbamazepine vs Lamotrigine in Epilepsy

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The results of this review are applicable primarily to persons with focal onset seizures, with 88% of included participants experiencing this type of seizure at baseline.

Treatment of New-Onset Epilepsy: AAN, AES Update Practice Guidelines

Treatment of New-Onset Epilepsy: AAN, AES Update Practice Guidelines

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An expert subcommittee was formed consisting of members of the AAN and AES to update the 2004 evidence-based guidelines on epilepsy treatment with AEDs.

Vagus Nerve Stimulation in Pediatric Epilepsy: Weighing the Risks and Benefits

Vagus Nerve Stimulation in Pediatric Epilepsy: Weighing the Risks and Benefits

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Studies that have evaluated the use of VNS in children, including those as young as 6 months old, and have generally concluded that it is well tolerated and improves quality of life.

Viral vector based gene therapies show promise for treating focal epilepsy [PreClinical]

Seizures are often associated with accumulation of extracellular glutamate due to the synchronous discharges of excitatory neurons.

New Formulation of Status Epilepticus Treatment To Be Reviewed

New Formulation of Status Epilepticus Treatment To Be Reviewed

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The NDA for IM/IV Captisol-Enabled Fosphenytoin has been accepted for review and given a Prescription Drug Fee User Act date, by the FDA.

Modifiable Midlife Risk Factors Linked to Late-Onset Epilepsy

Modifiable Midlife Risk Factors Linked to Late-Onset Epilepsy

Potentially modifiable risk factors in midlife are associated with the risk of developing late-onset epilepsy.

Addressing Psychiatric Comorbidities in Pediatric Epilepsy: Expert Opinions

Addressing Psychiatric Comorbidities in Pediatric Epilepsy: Expert Opinions

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Cognitive and linguistic deficits have been cited as risk factors for psychiatric comorbidity in pediatric epilepsy, along with family factors such as parenting style and quality of the parent-child relationship.

Disease-Specific ICD Code Helps Identify Infantile Spasms in Claims Data

Disease-Specific ICD Code Helps Identify Infantile Spasms in Claims Data

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Claims data spanning 4 years were obtained from a pediatric accountable care organization.

Evidence for Clobazam Monotherapy Use in Focal, Generalized Seizures Reviewed

Evidence for Clobazam Monotherapy Use in Focal, Generalized Seizures Reviewed

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The safety and efficacy of clobazam monotherapy in patients with new-onset focal or generalized seizures was investigated in a new Cochrane systematic review.

Weight-Adjusted Lacosamide Effective for Benzodiazepine-Resistant Status Epilepticus

Weight-Adjusted Lacosamide Effective for Benzodiazepine-Resistant Status Epilepticus

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The efficacy was reported to be significantly higher in patients who had taken benzodiazepines.

Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths

Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths

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Causes of death in patients with epilepsy were assessed to determine the presence of cardiac pathology.

Vigadrone Available for Refractory Complex Partial Seizures, Infantile Spasms

Vigadrone Available for Refractory Complex Partial Seizures, Infantile Spasms

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The FDA has approved an abbreviated New Drug Application for Vigadrone, the generic alternative to Sabril powder for oral solution.

Significant Changes in Serotonin Levels Observed Following Epileptic Seizures

Significant Changes in Serotonin Levels Observed Following Epileptic Seizures

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Investigators sought to examine whether seizures are capable of causing changes in serotonin levels in the peripheral circulation.

Next-Generation Sequencing May Improve Pediatric Epilepsy Tx

Next-Generation Sequencing May Improve Pediatric Epilepsy Tx

Next-generation sequencing can improve treatment efficacy and reduce hospitalization in children with drug-resistant epilepsy.

Epilepsy's Mobility Problem: Advocating for Changes in Transportation Laws, Public Resources

Epilepsy's Mobility Problem: Advocating for Changes in Transportation Laws, Public Resources

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In individuals who can adequately access healthcare appointments, medications, and other treatments, the combination of driving restrictions and sparse or nonexistent public transportation options interferes with daily living and their overall quality of life.

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

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Since MRI and EEG risk factors were retrospectively reviewed, the study was unable to analyze the temporal seizure burden or the volume of MRI injury, both of which may have provided greater insights into outcomes.

Therapeutic Everolimus Monitoring Range Thresholds Established for Tuberous Sclerosis Complex

Therapeutic Everolimus Monitoring Range Thresholds Established for Tuberous Sclerosis Complex

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The primary efficacy outcome was achieved in a higher percentage of patients in the exposure range of 9 to 15 ng/mL compared with patients in the 3 to 7 ng/mL and >7 to 9 ng/mL ranges.

Women With Epilepsy More Likely to Have Major Depressive Disorder

Women With Epilepsy More Likely to Have Major Depressive Disorder

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Investigators sought to determine the frequency of major depressive disorder in patients in epilepsy clinics.

Fycompa Granted Priority Review for Pediatric Indications

Fycompa Granted Priority Review for Pediatric Indications

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The sNDA included data from Study 311 (N=180), an ongoing, open-label, multicenter trial with an extension phase that evaluated the safety, tolerability, and exposure-efficacy relationship of Fycompa oral suspension as adjunctive therapy in children (4 to 11 years) with inadequately controlled POS or PGTC seizures.

Stroke Survivors Have Higher Risk for Subsequent Seizures Than General Population

Stroke Survivors Have Higher Risk for Subsequent Seizures Than General Population

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At 8 years, the cumulative rate of any hospitalization or emergency department visit for seizure was higher among patients with stroke vs the general population.

Rates of Pregnancy, Live Births Similar Among Women With and Without Epilepsy

Rates of Pregnancy, Live Births Similar Among Women With and Without Epilepsy

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The results of this study should help reassure and encourage women with epilepsy without a prior diagnosis of infertility or an associated disorder who are seeking pregnancy.

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