Sleep Disorders

Sleep and Circadian Alterations in Parkinson's: Understanding the Source for Smarter Treatment

Sleep and Circadian Alterations in Parkinson's: Understanding the Source for Smarter Treatment

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Sleep alterations often precede cognitive and motor symptoms in PD and appear during the prodromal phase of the disease.

Age, BMI Predict Obstructive Sleep Apnea Treatment Success

Age, BMI Predict Obstructive Sleep Apnea Treatment Success

Among patients with obstructive sleep apnea, older age and reduced BMI are predictors of upper airway stimulation treatment response.

Study IDs Risk Factors for Violent Sleep Disorder

Study IDs Risk Factors for Violent Sleep Disorder

Rapid eye movement sleep behavior disorder is more common among men, as well as those with psychological distress, mental illness, or PTSD.

FDA to Review Treatment for Jet Lag Disorder

FDA to Review Treatment for Jet Lag Disorder

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In the Phase 3 JET8 study (N=318), patients underwent a circadian challenge of 8 hours in advance to their usual bedtime.

Solriamfetol Feasible for Sleep Apnea-Related Tiredness

Solriamfetol Feasible for Sleep Apnea-Related Tiredness

Solriamfetol therapy, compared with placebo, results in improvements in wakefulness and sleepiness measures in patients with excessive sleepiness due to obstructive sleep apnea.

Montelukast With or Without Intranasal Steroids Evaluated for Pediatric OSA

Montelukast With or Without Intranasal Steroids Evaluated for Pediatric OSA

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A team of authors performed a systematic review of studies examining anti-inflammatory treatments for pediatric OSA through June 28, 2018 using PubMed/MEDLINE and 4 other databases.

REM Sleep Behavior Disorder Associated With Worse Cognitive Performance in PD-Susceptible Patients

REM Sleep Behavior Disorder Associated With Worse Cognitive Performance in PD-Susceptible Patients

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Participants in the RBD group had significantly worse performances on the Symbol Digit Modality Test compared with participants in the hyposmia and NMC cohorts.

Xyrem Approved for Use in Pediatric Patients With Narcolepsy

Xyrem Approved for Use in Pediatric Patients With Narcolepsy

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Efficacy in the pediatric population with narcolepsy was demonstrated in the Phase 2/3 EXPRESS study (N=106) which included patients aged 7 to 17 years with narcolepsy with cataplexy.

Novel Narcolepsy Treatment Gets Orphan Drug Designation

Novel Narcolepsy Treatment Gets Orphan Drug Designation

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The Company stated that they plan to begin a Phase 2 trial of AXS-12 before the end of 2018, with results anticipated for the first half of 2019.

Short Respiratory Event Duration Ups Mortality Risk in OSA

Short Respiratory Event Duration Ups Mortality Risk in OSA

For individuals with obstructive sleep apnea, those with short respiratory event duration have an increased risk for mortality.

Hypoglossal Nerve Stimulation Improves Objective Alertness, Sleep in Obstructive Sleep Apnea

Hypoglossal Nerve Stimulation Improves Objective Alertness, Sleep in Obstructive Sleep Apnea

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The investigators found a significant reduction in the mean preimplantation apnea-hypopnea index at 6 months after hypoglossal nerve stimulation.

Positive Results for Lemborexant in Insomnia Disorder Study

Positive Results for Lemborexant in Insomnia Disorder Study

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SUNRISE 2 is an ongoing long-term efficacy and safety study (N=900) of adults (aged 18 to 88 years) with insomnia disorder who have difficulty falling and/or staying asleep.

Digital Cognitive Therapy Eases Daytime Effects of Insomnia

Digital Cognitive Therapy Eases Daytime Effects of Insomnia

Digital CBT is effective in improving functional health, psychological well-being, and sleep-related quality of life in people reporting insomnia.

Oxygen Desaturation Index Predicts AFib Risk in Ischemic Stroke

Oxygen Desaturation Index Predicts AFib Risk in Ischemic Stroke

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Investigators observed a significant association between atrial fibrillation and increasing oxygen desaturation index.

Insufficient Sleep Tied to Unsafe Behaviors in High School Students

Insufficient Sleep Tied to Unsafe Behaviors in High School Students

For high school students, sleeping less than eight hours on an average school night is associated with increased odds of selected unsafe behaviors.

Many Older Adults Transition to Long-Term Benzodiazepine Use

Many Older Adults Transition to Long-Term Benzodiazepine Use

More than one-quarter of older adults newly prescribed benzodiazepine by an non-psychiatric clinician transition to long-term use.

Investigating the Effects of Z-Drugs in Dementia Patients With Sleep Disturbances

Investigating the Effects of Z-Drugs in Dementia Patients With Sleep Disturbances

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Existing data from the the UK Clinical Practice Research Datalink (CPRD) and 3 clinical studies of PwD were used to evaluate the association between Z-drug administration and the incidence of adverse events.

Sleep Apnea Linked to Changes in the Brain in Older Adults

Sleep Apnea Linked to Changes in the Brain in Older Adults

Obstructive sleep apnea is associated with changes to the structure of the brain that are seen in the early stages of dementia.

Acute Insomnia Found to Be Common Among Good Sleepers

Acute Insomnia Found to Be Common Among Good Sleepers

Acute insomnia is common among good sleepers, and about three-quarters of those with AI recover good sleep.

Insomnia Found to Be Common but Mild in Older Adults

Insomnia Found to Be Common but Mild in Older Adults

Insomnia is common in older community-dwelling adults, but usually mild.

Antidepressant Use for Insomnia: Is It Effective?

Antidepressant Use for Insomnia: Is It Effective?

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For this study, researchers identified 23 randomized controlled trials that included a total of 2806 adults with a primary diagnosis of insomnia to examine the relationship between antidepressant use and insomnia treatment.

Primary Care Can Effectively Manage Obstructive Sleep Apnea

Primary Care Can Effectively Manage Obstructive Sleep Apnea

Primary care management of obstructive sleep apnea is as effective and more cost-effective than in-laboratory diagnosis.

Factors Associated With Long-Term Psychotic Symptoms in Parkinson's

Factors Associated With Long-Term Psychotic Symptoms in Parkinson's

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The assessment of psychiatric symptoms relied on only one question in the MDS-UPDRS, potentially leading to underestimation of these symptoms in this cohort.

Predictors of Conversion to Neurodegenerative Disease in REM Sleep Behavior Disorder

Predictors of Conversion to Neurodegenerative Disease in REM Sleep Behavior Disorder

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Several prodromal symptoms in REM sleep behavior disorder are highly associated with conversion to neurodegenerative diseases.

Solriamfetol Associated With Improvement in Narcolepsy Types 1 and 2

Solriamfetol Associated With Improvement in Narcolepsy Types 1 and 2

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Patients in the 2 highest dosing groups saw significant, sustained improvements over the 12-week study.

Caffeine Therapy for Apnea of Prematurity Safe Over Long Term

Caffeine Therapy for Apnea of Prematurity Safe Over Long Term

Neonatal caffeine therapy for apnea of prematurity has no detrimental long-term effects and even improves some neurologic measures.

AASM: Medical Marijuana Should Not Be Used to Treat Sleep Apnea

AASM: Medical Marijuana Should Not Be Used to Treat Sleep Apnea

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Continuous positive airway pressure (CPAP) remains the mainstay of medical treatment for OSA.

CPAP Effective for Sleep Apnea Treatment Following Stroke

CPAP Effective for Sleep Apnea Treatment Following Stroke

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The combined analysis of the neurofunctional scales demonstrated an overall neurofunctional improvement with CPAP.

Nightmares Common in Military Personnel With Sleep Disturbance

Nightmares Common in Military Personnel With Sleep Disturbance

Comorbid disorders of depression, anxiety, PTSD, and insomnia are all associated with nightmares.

Reduced Cortical Thickness ID'd in Obstructive Sleep Apnea

Reduced Cortical Thickness ID'd in Obstructive Sleep Apnea

Female OSA patients had multiple regions of reduced cortical thickness in superior frontal lobe.

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