Generic Name and Formulations:
Minocycline (as HCl) 55mg, 65mg, 80mg, 105mg, 115mg; ext-rel tabs.
Valeant Pharmaceuticals, Inc
Indications for SOLODYN:
Inflammatory lesions of non-nodular moderate to severe acne.
Swallow whole. Give approximately 1mg/kg once daily for 12wks. Weight-based dosing (45–49kg): 45mg; (50–59kg): 55mg; (60–71kg): 65mg; (72–84kg): 80mg; (85–96kg): 90mg; (97–110kg): 105mg; (111–125kg): 115mg; (126–136kg): 135mg. Renal impairment: reduce dose or extend dosing intervals.
<12yrs: not established.
Not bioequivalent with other minocycline products. Monitor blood, renal, and hepatic function. Discontinue if superinfection, DRESS syndrome, or autoimmune syndromes develop. Monitor for visual disturbances. Renal or hepatic impairment. Avoid sun or UV light. Pregnancy (Cat.D), nursing mothers: not recommended.
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. May interfere with fluorescence test.
Headache, fatigue, dizziness, pruritus; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hyperpigmentation, hepatotoxicity, skin/hypersensitivity reactions (may be severe).
Neurology Advisor Articles
- FDA Approves Aimovig for Migraine Prevention
- Prediction Algorithm Stratifies ICH Patients at Risk for Hematoma Expansion
- Sports-Related Concussion Outcomes Predicted With Serum Neurofilament Light
- FDA: Lamotrigine Linked to Potentially Life-Threatening Adverse Reaction
- Psychological Therapies May Help Older Adults With Chronic Pain
- Amyloid Positivity Increases Risk for Cognitive Impairment in Dementia-Free Patients
- Valproic Acid-Related Adverse Fetal Outcomes May Be Linked to Placental Effects
- Risk of Dementia Up for Older Adults With Lowest Wealth
- Language Used in Medical Record Can Affect Patient Care
- Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics