Status Epilepticus

Factors Associated With Treatment Delays in Pediatric Refractory Status Epilepticus

Factors Associated With Treatment Delays in Pediatric Refractory Status Epilepticus

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The investigators concluded that these findings should help to identify targets for intervention to reduce the overall time to treatment in this population.

Consensus Statement: Defining Pediatric Status Epilepticus Syndromes

Consensus Statement: Defining Pediatric Status Epilepticus Syndromes

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The investigators hope that the consensus statement helps resolve several clinical questions in cases of pediatric new onset status epilepticus syndromes.

Continuous Infusion in Refractory Status Epilepticus Linked to Increased Mortality, Longer Hospital Stay

Continuous Infusion in Refractory Status Epilepticus Linked to Increased Mortality, Longer Hospital Stay

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Researchers compared outcomes between patients treated with continuous infusion or repeated doses of nonbenzodiazepine anti-seizure medication.

Duration of Refractory Status Epilepticus May Predict Neurologic Deficits

Duration of Refractory Status Epilepticus May Predict Neurologic Deficits

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Approximately one-third of pediatric patients with refractory convulsive status epilepticus develop neurologic deficits.

Buccal, Nasal Midazolam Most Cost-Effective for Pediatric Status Epilepticus

Buccal, Nasal Midazolam Most Cost-Effective for Pediatric Status Epilepticus

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Rectal diazepam is currently the only FDA-approved treatment for pediatric status epilepticus.

Brexanolone Safe, Tolerable as Adjunctive Therapy in Super-Refractory Status Epilepticus

Brexanolone Safe, Tolerable as Adjunctive Therapy in Super-Refractory Status Epilepticus

Brexanolone may help wean patients with super-refractory status epilepticus off of third-line agents.

In Refractory Status Epilepticus, Lacosamide May Be a Good Option

In Refractory Status Epilepticus, Lacosamide May Be a Good Option

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In patients with lorazepam-resistant status epilepticus, treatment with lacosamide had comparable efficacy and safety as sodium valproate.

Super-Refractory Status Epilepticus Poses a Significant Health and Economic Burden

Super-Refractory Status Epilepticus Poses a Significant Health and Economic Burden

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On average, pediatric patients spent more time in the ICU and accounted for a larger hospitalization cost.

Abnormal VEEG Is a Risk Factor for Recurrence After First Unprovoked Seizure

Abnormal VEEG Is a Risk Factor for Recurrence After First Unprovoked Seizure

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VEEG abnormalities were detected in 56.7% of patients, and these were a statistically significant predictor of recurring seizure.

Predicting Brain Atrophy Severity in Super-Refractory Status Epilepticus

Predicting Brain Atrophy Severity in Super-Refractory Status Epilepticus

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Surprisingly, the authors found that change in VBR did not correlate with functional outcomes.

Combined Severity Score Better Predicts Mortality in Status Epilepticus

Combined Severity Score Better Predicts Mortality in Status Epilepticus

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The mSTESS predicted mortality at a rate of 80.1%.

New Guideline for the Treatment of Convulsive Status Epilepticus

New Guideline for the Treatment of Convulsive Status Epilepticus

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AES releases a new, evidence-based treatment guideline for convulsive status epilepticus, the most common form of the condition associated with substantial mortality.

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