The investigators concluded that these findings should help to identify targets for intervention to reduce the overall time to treatment in this population.
The investigators hope that the consensus statement helps resolve several clinical questions in cases of pediatric new onset status epilepticus syndromes.
Continuous Infusion in Refractory Status Epilepticus Linked to Increased Mortality, Longer Hospital StayDecember 03, 2017
Researchers compared outcomes between patients treated with continuous infusion or repeated doses of nonbenzodiazepine anti-seizure medication.
Approximately one-third of pediatric patients with refractory convulsive status epilepticus develop neurologic deficits.
Rectal diazepam is currently the only FDA-approved treatment for pediatric status epilepticus.
Brexanolone may help wean patients with super-refractory status epilepticus off of third-line agents.
In patients with lorazepam-resistant status epilepticus, treatment with lacosamide had comparable efficacy and safety as sodium valproate.
On average, pediatric patients spent more time in the ICU and accounted for a larger hospitalization cost.
VEEG abnormalities were detected in 56.7% of patients, and these were a statistically significant predictor of recurring seizure.
Surprisingly, the authors found that change in VBR did not correlate with functional outcomes.
The mSTESS predicted mortality at a rate of 80.1%.
AES releases a new, evidence-based treatment guideline for convulsive status epilepticus, the most common form of the condition associated with substantial mortality.
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