Stroke News Archive
Systematic review and meta-analysis provides evidence that white matter hyperintensities, brain infarcts, and cerebral microbleeds indicate a significant increased risk for stroke, dementia, and death in community-dwelling older adults.
Results indicate that recurrent vascular event rate and changes in vascular status were different between patients with intracranial arterial dissection and those with intracranial atherosclerotic stenosis.
Researchers developed deep learning algorithms to individually detect up to 9 critical findings on head CT scans.
Quick Take:Effect of Cerebellar Stimulation on Gait and Balance Recovery in Patients With Hemiparetic Stroke: A Randomized Clinical Trial
Impairments in gait and balance are not uncommon after stroke, and are associated with poorer functional recovery.
Quick Take: Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial
The selective serotonin reuptake inhibitor fluoxetine is commonly used in treating depression and emotional lability after stroke.
Volume Perfusion CT Helps Differentiate Ictal Stroke Mimics, but Not Postictal, From Acute Ischemic Stroke
Patients were initially misjudged to have presented with an acute stroke instead of an epileptic seizure.
Researchers predict that an NIHSS score ≥6 for an infratentorial stroke may require more aggressive treatment than just thrombolysis alone.
Culturally tailored, skills-based strategies may be an important alternative to knowledge-focused approaches in achieving sustained vascular risk reduction and addressing racial/ethnic stroke disparities.
A significantly higher percentage of patients in the pharyngeal electrical stimulation group of the PHAST-TRAC trial were ready for decannulation after 3 days of treatment vs the sham control group.
Investigators explored the use of serum neurofilament light chain as a biomarker for primary and secondary neuroaxonal injury after ischemic stroke.
Investigators examine the association between LAD and vascular brain injury on brain MRI.
Dextroamphetamine Plus Physical Therapy Nonsuperior to Placebo for Improving Post-Stroke Motor Recovery
No significant difference was observed between the treatment and placebo arms in change in the Fugl-Meyer motor scores from baseline to 3-month follow-up.
The designation was granted to Revive Therapeutics, a company that specializes in cannabis-based pharmaceuticals.
For patients with ischemic stroke, infection during stroke hospitalization is associated with increased odds of 30-day readmission.
A review of data recorded in the National Health Interview Survey showed that cost-related nonadherence with medication decreased in stroke survivors following the implementation of the ACA.
Exposure to carbamazepine was associated with the highest risk for stroke, particularly ischemic stroke.
Investigators evaluated the association between modifiable cardiovascular disease risk factors at recommended levels and white matter hyperintensities and indices of cerebrovascular structure and function.
Alteplase was associated with 30.4% success in recanalization, while only 13.3% who did not receive alteplase had success.
Genetic and lifestyle factors are independently associated with incident stroke among men and women aged 40 to 73 years.
Higher blood pressure was predicted by higher posterior circulation involvement and bilateral disease.
One in two women and one in three men will develop dementia, stroke, or parkinsonism during their lifetime.
A higher percentage of PES-treated participants were ready for decannulation compared with those assigned to sham control.
The Montreal Cognitive Assessment administered within seven days after stroke can predict long-term cognitive and functional outcome and mortality.
Following adjustment, the mean change in correctly naming common objects was greater in patients undergoing A-tDCS vs sham tDCS.
A culturally tailored, skills-based educational intervention did not reduce systolic blood pressure at one year after stroke/transient ischemic attack.
The avoidance of SBP <120 mm Hg in individuals with acute ICH may help prevent cerebral ischemia and neurologic deterioration.
There are currently no other biomarkers that can predict the risk for recurrent stroke.
Models using 4 or 5 predictors have acceptable to good discrimination for determining additional intracerebral hemorrhage growth in patients with acute intracerebral hemorrhage.
Investigators observed a significant association between atrial fibrillation and increasing oxygen desaturation index.
The association of sleep duration with incident stroke varies by race and sex.
The risk of recurrence after incident venous thromboembolism is high, particularly among patients with cancer-related venous thromboembolism.
Strokes in people living with HIV are most frequently caused by large artery atherosclerosis.
The Get With the Guidelines-Stroke program includes measures such as neurologist assessment, rehabilitation evaluation, and education on stroke risk factors.
There is variation in the net clinical benefit of anticoagulants based on variation in published atrial fibrillation stroke rates.
Patients in the intervention group were fitted with an ambulatory exoskeleton, which works in accordance with the movements of the patient.
Rivaroxaban does not lower risk of symptomatic venous thromboembolism and related death in medical patients after hospital discharge, compared to placebo.
In the linear analysis, study investigators found no significant effect of magnesium on cognition.
The most frequent stroke mimic diagnoses included migraine and peripheral vertigo.
In patients with aphasia, use of anodal transcranial direct current stimulation demonstrated improved object naming compared to sham procedure.
Serum lactate at admission did not correlate with vasospasm or delayed cerebral ischemia development.
Increased Systolic Blood Pressure Variability Linked to Worse Neurologic Outcomes in Intracerebral Hemorrhage
The primary outcome was an unfavorable neurologic outcome, which was defined as a modified Rankin Scale score of 3 to 6 at 3 months following randomization.
Psychological distress is associated with myocardial infarction and stroke in men and women.
One in 8 patients with ACI experience ultra-early neurological deterioration during ambulance transport and initial evaluation at the emergency department.
Patients with a higher mean systolic blood pressure during follow-up had increased odds for brain infarcts compared with those with lower levels.
The investigators observed a high rate of accurate diagnosis for acute cerebral ischemia, hemorrhagic stroke, and stroke mimics in the cohort.
Breastfeeding is associated with a lower risk of stroke among older women, with a stronger correlation for longer duration of breastfeeding.
A variety of underlying mechanisms may be attributed to the role of statins in preventing bone-related disorders.
The root causes of the disparity reported among families of different income levels are unclear and deserve additional investigation.
Alteplase may increase the risk for symptomatic intracranial hemorrhage vs aspirin.
Data from patients with first-ever ischemic right-hemisphere stroke and visuospatial neglect were included.
Investigators identify clinical and neuroimaging markers associated with the presence of cortical superficial siderosis and the risk for recurrent ICH.
Investigators assessed the number of stroke survivors in the US taking antihypertensive medications to treat high blood pressure according to the 2017 ACC/AHA guidelines.
Quality improvement interventions were associated with fewer vascular events and less stroke disability over one year of follow up.
In this randomized controlled trial, administration of alteplase within 3 hours of mild stoke did not lead to a reduction in disability at 90 days post-stroke compared to aspirin.
Ultra-early neurological deterioration occurs in one in eight ambulance-transported patients with acute cerebrovascular disease.
Even with thorough testing, declaring a patent foramen ovale as the most likely culprit responsible for a cryptogenic stroke remains a challenge.
A combined test of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein assay results has high sensitivity for detection of intracranial injury among patients with TBI.
PFO closure plus antiplatelets recommended over antiplatelet therapy alone for patients younger than 60.
More adhesive-type interactions were observed between the thrombus and stent-retriever after thrombectomy in patients with acute ischemic stroke.
An inverse relationship was discovered between rising cholesterol levels and decreased risk for intracerebral hemorrhage in new statin users.
World Trade Center-related PTSD is a risk factor for myocardial infarction and stroke among workers involved in cleaning up the debris.
Stroke rates are lower at 30 days and five years after percutaneous coronary intervention than after coronary artery bypass grafting.
Contrast-enhanced transcranial Doppler sonography is a useful noninvasive bedside technique for detecting PFOs among elderly patients with TIA or nondisabling stroke.
Investigators assessed the impact of conscious sedation on outcomes in patients undergoing intra-arterial treatment for acute ischemic stroke.
Multivitamin/mineral supplementation seems not to be associated with cardiovascular disease outcomes.
Apixaban seems to be the safest direct oral anticoagulant compared with warfarin.
Transfeminine individuals have increased rates of VTE compared with cisgender men and cisgender women, with more pronounced differences for those initiating hormone therapy.
The prospective study was performed in patients ≥16 years of age with community-acquired bacterial meningitis.
For patients who experienced a TIA or minor stroke, the rate of a composite of stroke, acute coronary syndrome, or death from cardiovascular causes is 12.9 percent at five years.
A team of investigators sought to assess the efficacy and safety of cilostazol vs aspirin, both with and without probucol, a cholesterol-lowering agent, in Asian patients with ischemic stroke.
Transcranial Doppler Ultrasound Timing Critical for Beneficial Outcomes Following Stroke Thrombolysis
A team of investigators sought to assess whether the use of diagnostic transcranial Doppler ultrasound may delay initiation of intravenous thrombolysis in patients experiencing acute stroke.
A retrospective cohort study was conducted to assess the effect of surgical left atrial appendage occlusion on risk for readmission due to thromboembolism in older patients.
Investigators assessed the presence of cerebral microbleeds as a biomarker for identifying patients at increased risk for intracranial hemorrhage as a result of anticoagulation for atrial fibrillation.
Data from large Phase 3 studies showed that treatment with rivaroxaban was found to be safe and effective in older patients.
Investigators retrospectively reviewed treatment patterns and long-term outcomes in 30,626 patients with ischemic stroke and AF who had these data recorded in 4 Danish healthcare registries.
Patients with intracerebral hemorrhage who were admitted to acute stroke units were randomly assigned to either 1 gram intravenous tranexamic acid followed by an 8-hour infusion of 1 gram tranexamic acid or matched placebo.
At 90-day follow-up, the data and safety monitoring board halted the trial after it found that approximately 84% of patients had experienced both a lower risk and higher risk for major ischemic events and major hemorrhage compared with aspirin only, respectively.
During a median follow-up period of 11 months, a total of 172 and 160 patients in the rivaroxaban and aspirin groups, respectively, experienced a recurrent stroke of any type or a systemic embolism.
Approximately half of composite outcome events and up to half of the stroke events occurred during the second through fifth years of the analysis.
Lack of superiority of rivaroxaban for secondary prevention of embolic stroke of undetermined source
At a median follow-up of eleven months, rivaroxaban was not superior to aspirin for prevention of secondary stroke after an initial primary embolic stroke of undetermined source.
Investigators conducted 2 retrospective cohort studies to determine whether patients with resolved AF were at an increased risk for stroke or TIA and all-cause mortality compared with matched controls with unresolved AF.
Roche is expected to launch the CoaguChek Vantus system, the first Bluetooth-enabled, self-testing device for coagulation monitoring, this summer.
Black and Hispanic patients are at higher risk for stroke recurrence than white patients.
Under the 2017 ACC/AHA hypertension guidelines, there would be a substantial increase in the proportions of stroke survivors with hypertension.
Stroke patients with unknown time of stroke onset and DWI-FLAIR mismatch indicative of a stroke within the prior 4.5 hours who were randomized to alteplase were more likely to have a favorable outcome at 90 days than those receiving placebo.
At 8 years, the cumulative rate of any hospitalization or emergency department visit for seizure was higher among patients with stroke vs the general population.
Although women demonstrated greater participation restriction compared with men in the unadjusted analysis, there was no difference between men and women after accounting for age, stroke severity, and prestroke dependency.
The combination of clopidogrel and aspirin is associated with reduced risk of major ischemic events but increased risk of major hemorrhage among patients with minor ischemic stroke.
For patients with ischemic stroke with an unknown time of onset, intravenous alteplase is associated with better functional outcome than placebo.
While developing the hematoma expansion prediction score, associations between hematoma expansion and blend sign, any intrahematoma hypodensity, and time from onset to noncontrast computed tomography <2.5 hours were found.
Congenital Heart Disease, Hispanic Ethnicity Associated With Increased Mortality in Pediatric Arterial Ischemic Stroke
The investigators were unable to determine which type of congenital heart disease or which type of ventricular assist device, if used, played a role in mortality outcomes.
The findings from this trial are limited to only ischemic stroke patients with large-vessel occlusion who are deemed appropriate for thrombolysis.
There were no differences between the ceftriaxone and standard care groups in terms of institutional care resources, out-of-pocket expenses, or productivity losses.
Sickle cell trait is not associated with ischemic stroke and should not be relied upon as a sole predictor of stroke in African Americans.
A shortened summary cognitive score consisting of action speed, executive function, and language may help diagnose poststroke NCD.
For adults, frequent sauna bathing is associated with reduced risk of future stroke.
The lack of a comparator group as well as the relatively small patient sample represents potential limitations of this study.
Investigators performed a pre-planned secondary analysis of the open-label, randomized Antihypertensive Treatment of Acute Cerebral Hemorrhage 2 study, specifically on the magnetic resonance images obtained during the intensive blood pressure lowering portion of the trial.
Variations in reperfusion rates as well as MRI assessments among included studies represent possible limitations of this meta-analysis.
For patients undergoing surgical aortic valve replacement, previous stroke is a risk factor for recurrent ischemic stroke and major adverse cardiovascular events.
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