Intraarterial Chemo-Radiation Increases Risk of Cerebral Infarctions

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Intraarterial Chemo-Radiation Increases Risk of Cerebral Infarctions
Intraarterial Chemo-Radiation Increases Risk of Cerebral Infarctions

HealthDay News — Intraarterial chemoradiotherapy (CRT) for head and neck cancer is tied to a higher incidence of cerebral infarction compared to intravenous CRT, according to a study published in Head & Neck.

Sayaka Suzuki, MD, from the University of Tokyo, and colleagues used the Diagnosis Procedure Combination database (2010 to 2013) to identify patients with head and neck cancer receiving platinum-based chemotherapy and concurrent radiotherapy, either intraarterial or intravenous CRT (propensity score-matched 1:4).

The researchers found that the occurrence of cerebral infarction was significantly higher in the intraarterial CRT group than in the intravenous CRT group (11 of 775 vs 12 of 3,100; P = 0.002). There was no significant difference noted in either mucosal toxicity or febrile neutropenia.

"This result is useful when considering the procedure-related risks and the potential benefits of intraarterial CRT," the authors write.

Reference

Suzuki S, Yasunaga H, Matsui H, Fushimi K, Saito Y, Yamasoba T. Cerebral infarction after intraarterial and intravenous chemoradiotherapy for head and neck cancer: A retrospective analysis using a Japanese inpatient database. Head Neck. 2016; doi;10.1002/hed.24439.

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