Identifying Clinical Signs of Recanalization in Stroke

Share this content:

the Neurology Advisor take:

Neurologic improvement along with a drop in systolic blood pressure following intravenous tissue plasminogen activator treatment in stroke patients may be a clinical sign of recanalization, according to a study published in JAMA Neurology.

Nandakumar Nagaraja, MD, of the University of Iowa and the National Institute of Neurological Disorders and Stroke’s Stroke Diagnostics and Therapeutics section, and colleagues, compared neurologic improvement to the rate of recanalization in 17 patients with proximal middle cerebral artery occlusion treated with intravenous tissue plasminogen activator. The researchers assessed recanalization status on 24-hour magnetic resonance angiography.

Upon 24-hour magnetic resonance angiography, 3 patients had no recanalization, 8 had partial recanalization, and 6 had complete recanalization. 24 hours after thrombolysis, neurologic improvement with a concurrent decline in systolic blood pressure of 20 mm Hg or more was observed in four patients with partial recanalization, four with complete recanalization and none of the patients with no recanalization.

The researchers concluded that neurologic improvement seen in concurrence with a decrease in systolic blood pressure of 20 mm Hg or greater following intravenous tissue plasminogen activator treatment could be a clinical sign of recanalization, but stressed that the results need to be confirmed in a larger study group. 

Identifying Clinical Signs of Recanalization in Stroke
Identifying Clinical Signs of Recanalization in Stroke

This study explores the possible association between neurologic improvement and recanalization in stroke patients treated with intravenous tissue plasminogen activator. 

Nandakumar Nagaraja, MD, of the University of Iowa and the National Institute of Neurological Disorders and Stroke's Stroke Diagnostics and Therapeutics section, and colleagues, hypothesized that neurologic improvement with concurrent decline in blood pressure may be a clinical sign of recanalization after intravenous tissue plasminogen activator. The researchers confirmed the association, but said results need to be confirmed in a larger cohort.

READ FULL ARTICLE From archneur.jamanetwork.com
You must be a registered member of Neurology Advisor to post a comment.

Sign Up for Free e-newsletters



CME Focus