β-amyloid (Aβ) and cerebrovascular disease burden have divergent effects on longitudinal default mode network and executive control network functional connectivity changes in amnestic MCI and subcortical vascular MCI.
The majority of older adults diagnosed with dementia do not receive specialty care.
Investigators addressed the association between long-term use of hydroxychloroquine therapy and the risk for Alzheimer disease.
Results of a safety review have led to the discontinuation of phase 3 clinical studies of elenbecestat, an investigational oral BACE (beta amyloid cleaving enzyme) inhibitor, which was being assessed for early Alzheimer disease (AD) treatment.
A phase 3 trial evaluating pimavanserin (Acadia) for the treatment of dementia-related psychosis has been stopped early due to positive findings in a planned interim efficacy analysis.
Use of hearing aids is associated with lower risks for being diagnosed with Alzheimer disease, dementia, depression, anxiety, and injurious falls among elderly adults diagnosed with hearing loss.
Evidence to date suggests that the risk for all-cause dementia is 40% to 60% higher in patients with type 1 or type 2 diabetes.
Patients with Alzheimer disease who participated in elastic resistance exercises showed changes in depressive symptoms, muscle function, and muscle mass.
Analysis of participants in the Atherosclerosis Risk in Communities (ARIC) study showed individuals who had sustained midlife and late-life hypertension had an increased risk of subsequent dementia compared with those who remained normotensive.
Adherence to the Life Simple 7 ideal cardiovascular health recommendations in midlife is associated with reduced incidence of dementia later in life.
