Umibecestat Alzheimer Disease Prevention Trials Discontinued
Two pivotal phase 2/3 studies investigating umibecestat (CNP520) for the prevention of Alzheimer disease have been discontinued due to worsening in some measures of cognitive function.
Alzheimer Disease and Dementia
Nilvadipine Increases Hippocampal Cerebral Blood Flow in Alzheimer Disease
Blood pressure reduction with nilvadipine resulted in an increase in hippocampal cerebral blood flow while global flow remained stable.
Alzheimer Disease Markers Predict Subsequent Decline in Mild Cognitive Impairment
Age and Alzheimer disease biomarkers are associated with decline in patients with mild cognitive impairment who initially reverted to normal cognition.
Cognitive Decline Associated With Successive Amyloid-Beta and Tau Changes
Older adults with an increase in amyloid-β plaques followed by increased tau neurofibrillary tangles have shown lower cognition after 7 years.
Nilvadipine Increases Cerebral Blood Flow in the Hippocampus
For patients with mild-to-moderate Alzheimer disease, treatment with nilvadipine lowers systolic blood pressure and increases cerebral blood flow (CBF) in the hippocampus.
Circulating Cholesterol Levels and Early-Onset AD: Is There a Link?
Study showed an association between early-onset Alzheimer disease and higher levels of low-density lipoprotein cholesterol independent of the effects of APOE, as well as demonstrated enrichment of rare coding variants of APOB.
How Virtual Reality Can Aid in Early Diagnosis of Alzheimer Disease
An entorhinal cortex-based virtual reality navigation task can differentiate patients with mild cognitive impairment at low and high risk for developing dementia.
Higher Serum Urate Associated With Lower Risk for Dementia
Prospective population-based study explores relationship between serum urate concentration and risk for dementia.
FDA Holds First Hearing to Explore Safety and Efficacy of CBD Products
CBD products have swamped the market due to change in federal law, not because of new medical evidence
Plasma Tau Levels Associated With Survival Time in Sporadic Creutzfeldt-Jakob Disease
The total tau concentration measured in either CSF or blood is strongly associated with survival time in sporadic Creutzfeldt-Jakob disease.
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