Zotiraciclib Granted Orphan Drug Designation for Treatment of Glioma
The Food and Drug Administration (FDA) has granted Orphan Drug Designation to zotiraciclib (Adastra Pharmaceuticals) for the treatment of glioma.
Brain Tumors
Visual Dysfunction an Important Element in Morbidity of Pituitary Adenoma
Visual symptoms are a vital component of the morbidity encountered in patients with pituitary adenoma, can present at all stages of the disease, and may negatively affect daily activities and overall quality of life, a new review claims.
Computer-Assisted Diagnosis Aids Detection of Glioma Growth
Computer-assisted diagnosis (CAD) can help physicians detect growth of low-grade gliomas.
Contrast-Enhanced MRI Characterization of Brain Cancers
According to researchers, neovascularization is more common in glioblastoma, and extravasation is more common in primary CNS lymphoma.
Combining CAR-T and BiTE in Models of Glioblastoma Multiforme
This study involved the engineering of CAR-T cells specific for the EGFRvIII antigen to also secrete bispecific T cell engagers (BiTEs) against wild-type EGFR.
Neoadjuvant PD-1 Blockade Seems Effective in Glioblastoma
Neoadjuvant administration of programmed cell death protein 1 (PD-1) blockade seems to enhance local and systemic antitumor immune response in glioblastoma.
Statins, NSAIDS Have No Apparent Survival Benefit for Grade IV Glioma
In certain parts of the analysis, the use of selective COX-2 inhibitors and metamizol was associated with inferior patient survival.
Novel Glioblastoma Treatment Granted Orphan Drug Designation
In preclinical models, the inhibition of phosphorylated STAT3 (p-STAT3) by WP1066 resulted in the direct attack of various tumor cells.
Sex Differences ID’d in Response to Glioblastoma Treatment
Standard therapy is more effective for female vs male patients with glioblastoma.
Nivolumab + Ipilimumab Shows Efficacy for Untreated Brain Mets
For patients with melanoma and untreated brain metastases, nivolumab combined with ipilimumab shows clinically meaningful efficacy.
