Nivolumab + Ipilimumab Shows Efficacy for Untreated Brain Mets
For patients with melanoma and untreated brain metastases, nivolumab combined with ipilimumab shows clinically meaningful efficacy.
Cancer
No Clear Benefit for Anticoagulants Over Antiplatelets in Stroke Patients With Cancer
This is the first clinical trial to compare antiplatelet and anticoagulation therapy in patients with cancer and ischemic stroke.
Clinical Factors Associated With Pediatric Brain Neoplasms
A study pinpointed clinical factors associated with pediatric brain neoplasms to assist clinicians in making neuroimaging decisions.
Seizure Incidence Stable in Prostate Cancer Treated With Enzalutamide
Treatment with enzalutamide for metastatic castration-resistant prostate cancer patients is not linked with increased seizure incidence.
Temozolomide Plus Radiotherapy Improves Survival in Non-Co-Deleted Glioma
1p/19q non-co-deleted anaplastic gliomas are associated with lower sensitivity to chemotherapy and worse prognosis than 1p/19q co-deleted tumors.
Characteristics of Neurotoxicity After CD19 CAR-T Cell Infusion
Patients with severe neurotoxicity have evidence of endothelial activation.
PD-1 Therapy for Cancer Increases Risk for Neurological Complications
The clinical spectrum and optimal treatment approach for PD-1-related neurological complications is not clear.
Immunosuppressant Use May Increase Cancer Risk in Multiple Sclerosis
It is important to consider long-term risks and outcomes when choosing an appropriate therapy for multiple sclerosis.
Cognitive Impairment Not Common Post-Skull Radiation
Most patients undergoing skull base irradiation for cancer do not have detectable cognitive impairment.
Postoperative Stereotactic Radiosurgery Reduces Recurrence After Metastases Resection
The use of postoperative stereotactic radiosurgery could be a substitute for whole-brain radiotherapy, which has been linked to cognitive adverse effects.
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