Hydroxychloroquine Use Not Linked With Risk for Alzheimer Disease
Investigators addressed the association between long-term use of hydroxychloroquine therapy and the risk for Alzheimer disease.
Dementia
Trials Investigating Elenbecestat in Early Alzheimer Disease Discontinued
Results of a safety review have led to the discontinuation of phase 3 clinical studies of elenbecestat, an investigational oral BACE (beta amyloid cleaving enzyme) inhibitor, which was being assessed for early Alzheimer disease (AD) treatment.
Imaging Technique May Help Predict Stroke-Related Dementia
Diffusion tensor image segmentation technique, which characterizes microstructural damage across the cerebellum, identifies damage in cerebral small vessel disease and can predict dementia.
Improving Delirium Detection in the Acute Setting: An Expert Interview
Delirium is highly prevalent in critical care, especially among elderly patients and individuals with dementia. Although rates vary widely across studies, findings suggest delirium affects more than 15% of hospitalized patients. For additional discussion regarding this topic, Neurology Advisor interviewed Leopoldo Pozuelo, MD, MBA, FACP, FACLP, clinical vice chair of psychiatry and psychology at the Cleveland Clinic in Ohio.
Lack of Evidence for Cognitive Screening in Older Adults, According to USPSTF
The USPSTF concludes that the evidence is currently inadequate for weighing the benefits and harms of screening for cognitive impairment among older adults.
Trial Investigating Pimavanserin for Dementia-Related Psychosis Stopped Early Due to Positive Finding
A phase 3 trial evaluating pimavanserin (Acadia) for the treatment of dementia-related psychosis has been stopped early due to positive findings in a planned interim efficacy analysis.
Hearing Aid Use Tied to Lower Risk for Dementia, Depression, Falls
Use of hearing aids is associated with lower risks for being diagnosed with Alzheimer disease, dementia, depression, anxiety, and injurious falls among elderly adults diagnosed with hearing loss.
Marriage Associated With Lower Dementia Risk
People who remain married in older age may have a lower dementia risk.
Midlife Hypertension Tied to Changes in Late-Life Brain Structure
Investigators studied the effects of midlife high or increasing blood pressure on late-life brain structure.
Midlife to Late-Life Hypertension May Predict Dementia Development
Analysis of participants in the Atherosclerosis Risk in Communities (ARIC) study showed individuals who had sustained midlife and late-life hypertension had an increased risk of subsequent dementia compared with those who remained normotensive.
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