Widowhood Tied to More Rapid Cognitive Decline Among Elderly
Rate of cognitive decline was even faster among widowed participants with higher β-amyloid levels at baseline.
Dementia
Anticholinergic Medications for Overactive Bladder May Increase Risk for Dementia
Among patients with OAB, anticholinergic medication use appears to be associated with an increased risk of new onset dementia when compared with beta-3 agonist use, according to the findings of a retrospective population-based cohort study.
Gene Therapy for Frontotemporal Dementia With a GRN Mutation Gets Fast Track Status
The FDA has granted Fast Track designation to PR006 (Prevail Therapeutics), an experimental gene therapy, to slow the progression of frontotemporal dementia with a GRN mutation.
MRI-Based Small Vessel Disease Score Predicts Risk for Dementia
A simple SVD score using MRI scans, may aid in identifying patients with SVD who are likely to develop cognitive decline.
USPSTF: Evidence Lacking for Cognitive Impairment Screening
The USPSTF states the balance of benefits and harms of cognitive impairment screening for older adults cannot be established due to lack of evidence.
Investigational Therapies Miss Primary End Point in Autosomal Dominant Alzheimer Disease Trial
Topline data were announced from the phase 2/3 DIAN-TU study of solanezumab (Eli Lilly) and gantenerumab (Genentech) in patients at risk for or with dominantly inherited Alzheimer disease.
Psychotropic Prescribing Trends Differ By Race Among Patients With Dementia
Compared with their peers, Asian patients with dementia were less likely to be prescribed antidementia drugs, and they received these drugs for fewer days per year.
Dementia Related Screening in Primary Care Not Harmful
No harms come from screening for Alzheimer disease and related dementias (ADRDs) in primary care.
Active Lifestyle May Protect Against Familial Frontotemporal Dementia
A physically and mentally active lifestyle may protect against frontotemporal dementia even in people at established genetic risk.
Self-Perceived Risk for Dementia Associated With Mental Health, Race/Ethnicity
Survey data published in JAMA Neurology indicate that approximately half of US adults perceive themselves to be at least somewhat likely to develop dementia.
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