HTT CAG Repeat Size, Age at Onset Associated With Huntington Disease Progression
Investigators sought to assess factors contributing to progression of functional, cognitive, and motor impairment in Huntington disease.
Huntington Disease
Salivary Levels of Total Huntington Protein Promising as Biomarker for Huntington Disease
Measurement of the disease protein huntingtin in saliva may be promising as an accessible, noninvasive biomarker to predict symptom severity and disease course in individuals with Huntington disease.
Novel Therapy May Improve Symptoms in Early Huntington Disease
Researchers found that high doses of the novel antisense oligonucleotide were associated with lower concentrations of mutant huntingtin protein in the cerebrospinal fluid and brain.
Plasma Neurofilament Light Indicative of Neuronal Damage in Huntington Disease
In both the cortical and subcortical gray matter and white matter, higher baseline Nfl concentrations were associated with reduced brain volume.
Caffeinated, Sugary Soda Consumption Associated With Early Onset of Huntington Disease
Sugar found in caffeinated soda is associated with increased systemic inflammatory processes that may in turn be associated with neurodegeneration.
Exercise, Physical Therapy May Provide Long-Term Functional Improvement in Huntington Disease
Interventions aimed at motor and cognitive impairments in Huntington disease may result in long-term functional improvement.
Defining Unique Needs for Palliative and Hospice Care in Huntington Disease
Research has shown significant gaps in knowledge on palliative services among neurology residents, resulting in low referral rates.
Daily Creatine Fails to Show Benefits in Early Huntington Disease
Despite promising results in earlier studies, researchers found no benefit for creatine in patients with early Huntington disease.
Evaluating the Effects of Treatment Conversion for Huntington’s Chorea
Overnight treatment conversion from tetrabenazine to deutetrabenazine in patients with HD was found to be safe.
Neurofilament Light Protein Shows Strong Potential as Biomarker for Huntington’s Disease
Investigators examined blood plasma samples taken annually from a cohort of 201 huntingtin gene (HTT) carriers.
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