Valbenazine Improves Chorea in Patients With Huntington Disease
The phase 3 KINECT-HD study included 128 adults 18 to 75 years of age who were diagnosed with chorea associated with HD.
Huntington Disease
Amyotrophic Lateral Sclerosis Prevention: Neurodegenerative Diseases Offer Insight
Researchers sought to develop a “roadmap” to early intervention and disease prevention for ALS by observing advances in neurodegenerative diseases with a presymptomatic period.
Altered Basal Ganglia Connectivity Tied to Apathy, Motor Signs in Huntington Disease
The researchers sought to determine whether motor signs in Huntington disease (HD) would be associated with altered indirect pathway connectivity, and whether apathy in early HD is linked to change in direct pathway connectivity.
PET With 11C-UCB-J Detects Extrastriatal Changes in Early Huntington Disease
In a PET imaging study, researchers assessed synaptic damage and its clinical correlates in early Huntington disease in vivo.
Structural MRI and Disease Model Helps Predict Huntington Disease Timeline
Using data from 2 of the largest cohort imaging studies in Huntington disease (HD), researchers utilized a disease progression model to learn individual-level disease times and reveal a new timeline of structural MRI changes in HD.
Huntington Disease May Be Undertreated and Current Monotherapies Inadequate
Investigators used data from the Enroll-HD registry to assess patterns of treatment for chorea in patients with Huntington disease.
Cortical Atrophy More Likely in Patients With Motor-Onset in Huntington Disease
Researchers analyzed brain MRI characteristics of patients with Huntington disease and related them to the major manifesting symptoms at clinical onset.
Predictors of Persistence to Deutetrabenazine Identified in Huntington Disease and Tardive Dyskinesia
Researchers assessed predictors of persistence and discontinuation of deutetrabenazine in patients with Huntington disease and tardive dyskinesia.
Avoiding ‘Evidence-Biased’ Care: Challenges of Neurodegenerative Disease Focus Groups
In research settings, including patients with neurodegenerative diseases presents challenges regarding consent, communication, and ability to participate that must be addressed in order to avoid evidence-biased care.
Clinical Benefits of Multidisciplinary Rehabilitation in Premanifest HD
Participants in the multidisciplinary intervention group had significant improvements in verbal learning and memory, attention, cognitive flexibility, and processing speed.
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