New Diagnostic Criteria and Categories for Huntington Disease Proposed by Movement Disorder Society
The Movement Disorder Society Task Force recently published a proposal for new diagnostic criteria for 3 Huntington disease categories.
Huntington Disease
Most At-Risk Opt Out of Genetic Testing for Huntington Disease
The vast majority of people at risk for Huntington disease (HD) choose not to be tested preemptively, mainly because there is no cure for the disease.
Trial Supports Further Development of Huntington Antisense Oligonucleotide Therapy
Antisense oligonucleotide drug HTTRx reduced the concentration of mutant huntingtin protein in the cerebrospinal fluid of persons with Huntington disease.
Identifying Predictors of Suicidal Behavior in Huntington Disease
Researchers sought to identify variables that were associated with suicidal ideation or behavior in patients with Huntington disease.
HTT CAG Repeat Size, Age at Onset Associated With Huntington Disease Progression
Investigators sought to assess factors contributing to progression of functional, cognitive, and motor impairment in Huntington disease.
Salivary Levels of Total Huntington Protein Promising as Biomarker for Huntington Disease
Measurement of the disease protein huntingtin in saliva may be promising as an accessible, noninvasive biomarker to predict symptom severity and disease course in individuals with Huntington disease.
Novel Therapy May Improve Symptoms in Early Huntington Disease
Researchers found that high doses of the novel antisense oligonucleotide were associated with lower concentrations of mutant huntingtin protein in the cerebrospinal fluid and brain.
Plasma Neurofilament Light Indicative of Neuronal Damage in Huntington Disease
In both the cortical and subcortical gray matter and white matter, higher baseline Nfl concentrations were associated with reduced brain volume.
Caffeinated, Sugary Soda Consumption Associated With Early Onset of Huntington Disease
Sugar found in caffeinated soda is associated with increased systemic inflammatory processes that may in turn be associated with neurodegeneration.
Exercise, Physical Therapy May Provide Long-Term Functional Improvement in Huntington Disease
Interventions aimed at motor and cognitive impairments in Huntington disease may result in long-term functional improvement.
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