HTT CAG Repeat Size, Age at Onset Associated With Huntington Disease Progression
Investigators sought to assess factors contributing to progression of functional, cognitive, and motor impairment in Huntington disease.
Investigators sought to assess factors contributing to progression of functional, cognitive, and motor impairment in Huntington disease.
Measurement of the disease protein huntingtin in saliva may be promising as an accessible, noninvasive biomarker to predict symptom severity and disease course in individuals with Huntington disease.
Researchers found that high doses of the novel antisense oligonucleotide were associated with lower concentrations of mutant huntingtin protein in the cerebrospinal fluid and brain.
In both the cortical and subcortical gray matter and white matter, higher baseline Nfl concentrations were associated with reduced brain volume.
Sugar found in caffeinated soda is associated with increased systemic inflammatory processes that may in turn be associated with neurodegeneration.
Interventions aimed at motor and cognitive impairments in Huntington disease may result in long-term functional improvement.
Research has shown significant gaps in knowledge on palliative services among neurology residents, resulting in low referral rates.
Despite promising results in earlier studies, researchers found no benefit for creatine in patients with early Huntington disease.
Overnight treatment conversion from tetrabenazine to deutetrabenazine in patients with HD was found to be safe.
Investigators examined blood plasma samples taken annually from a cohort of 201 huntingtin gene (HTT) carriers.