Predictors of Conversion to Neurodegenerative Disease in REM Sleep Behavior Disorder
Several prodromal symptoms in REM sleep behavior disorder are highly associated with conversion to neurodegenerative diseases.
Lewy Body Dementia
Dementia With Lewy Bodies Benefits From Adjunctive Zonisamide
Zonisamide as an adjunct to levodopa therapy improves parkinsonism in patients with dementia with Lewy bodies.
Atypical Parkinsonian Disorders: Reviewing the Complex Web of Proteinopathies
While parkinsonian disorders share a common mechanism of protein aggregation, manifestations are quite varied.
Risk for Death Significantly Increased in Patients With Synucleinopathies
Patients with multiple system atrophy with parkinsonism face the greatest risk for death among synucleinopathies.
Alzheimer’s Pathologies in Synucleinopathies Indicates Dementia Course
Increasing severity of AD pathology inversely correlated to decreases in time from motor symptoms to dementia onset and death.
Preserved Hippocampal Volume in MCI Predicts Progression to Lewy Body Dementia
Patients with mild cognitive impairment with preserved hippocampal volume are at increased risk for dementia with Lewy bodies vs Alzheimer disease.
When It’s Not Alzheimer’s: The Differential Diagnosis of Dementia With Lewy Bodies
According to a 2010 report based on a survey of caregivers of people with DLB, 78% of cases were initially misdiagnosed.
Retinal Imaging Identifies Disease Progression, Differentiation of Synucleinopathies
OCT can precisely measure changes to the retinal structure.
Addressing REM Sleep Behavior Disorder in Parkinson’s
Over 60% of people with Parkinson’s disease will have REM sleep behavior disorder, endangering them and their partners during the night.
Antibodies Targeting Alzheimer’s May Benefit Other Prion Diseases
Monoclonal antibodies targeting tau and beta amyloid in Alzheimer’s disease may also benefit other neurodegenerative diseases.
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