Baclofen Improves Excessive Daytime Sleepiness in Narcolepsy
Investigators sought to determine whether baclofen might be an effective treatment for excessive daytime sleepiness and sleep fragmentation in patients with narcolepsy.
Narcolepsy
Xyrem Approved for Use in Pediatric Patients With Narcolepsy
Efficacy in the pediatric population with narcolepsy was demonstrated in the Phase 2/3 EXPRESS study (N=106) which included patients aged 7 to 17 years with narcolepsy with cataplexy.
Novel Narcolepsy Treatment Gets Orphan Drug Designation
The Company stated that they plan to begin a Phase 2 trial of AXS-12 before the end of 2018, with results anticipated for the first half of 2019.
Solriamfetol Associated With Improvement in Narcolepsy Types 1 and 2
Patients in the 2 highest dosing groups saw significant, sustained improvements over the 12-week study.
FDA Accepts NDA for Narcolepsy, OSA-Related Sleepiness Treatment
The FDA has accepted the New Drug Application for solriamfetol for the treatment of sleep disorders.
Sodium Oxybate May Be Effective for Cataplexy in Pediatric Patients With Narcolepsy
The US Food and Drug Administration requested that sodium oxybate be studied in pediatric patients.
Increased Rates of Narcolepsy, Hypersomnia Linked to H1N1 Vaccine
After influenza infection, the risk for narcolepsy was increased by 2- to 3-fold overall.
Narcolepsy Symptoms Worsen as Parkinson’s Progresses
Narcolepsy symptoms were most severe in patients taking dopamine agonists.
Narcolepsy and Autoimmune Response: The Missing Link
Researchers are nearly convinced narcolepsy is the result of an autoimmune response, but one crucial factor is still missing.
Sodium Oxybate Improves Sleepiness in Narcolepsy Without Cataplexy
Sodium oxybate, alone or in combination with modafinil, improved excessive sleepiness in patients with narcolepsy both with and without cataplexy.
