Sleep Disturbances in Alzheimer Disease Tied to Loss of ‘Wakeful’ Neuron
Researchers sought to examine the association between the number of important subcortical wake-promoting neurons and clinical sleep phenotypes in patients with AD or PSP.
Neurodegenerative Diseases
Stress and Stress Susceptibility Effects on the Motor Cortex and its Function
Male mice were exposed to chronic stress using a social defeat stress experiment. Mice were assessed for behavioral deviations and impacts to motor learning after the stress experiment as well as neural changes due to stress.
FDA Advisory Panel Narrowly Votes Against New ALS Drug
In a close vote, an advisory panel for the US Food and Drug Administration decided not to recommend the approval of an experimental drug for amyotrophic lateral sclerosis (ALS).
FDA Panel Votes on Fixed-Dose Combination Therapy for ALS
AMX0035 is an oral, fixed-dose coformulation of sodium phenylbutyrate and taurursodiol, also known as ursodoxicoltaurine.
GBA Variants Impact Cognitive Status in Amyotrophic Lateral Sclerosis
Researchers sought to determine the effect GBA variants have on cognitive status in patients with amyotrophic lateral sclerosis.
Statin Therapy as a Precision Prevention Approach for Neurodegenerative Diseases
In a retrospective analysis, researchers assessed the effect of statin therapy on the incidence of Alzheimer disease and other age-related neurodegenerative diseases (NDD), and whether its effect on NND risk varies among molecules, sex, or age groups.
Spinal Cord Gray Matter Atrophy in Post-Polio Syndrome Tied to Functional Decline
Researchers sought to assess the incidence of spinal cord gray matter atrophy in patients with post-polio syndrome and its associations with muscle strength and functional decline.
Modifiable Risk Factors Tied to MS Diagnosis, Neurodegeneration
Smoking is associated with higher odds of being diagnosed with multiple sclerosis (MS), and high alcohol intake is associated with retinal features indicative of more severe neurodegeneration in individuals with MS.
Serum ADMA Level as a Prognostic Biomarker for Amyotrophic Lateral Sclerosis
Researchers sought to investigate the association between serum asymmetric dimethylarginine (ADMA) levels and the progression and prognosis of amyotrophic lateral sclerosis, and to compare cerebrospinal fluid and serum ADMA levels with other ALS biomarkers.
Gender-Specific Lipid and Hypermetabolism Risk Profiles for Amyotrophic Lateral Sclerosis
In a retrospective study, researchers assessed the predictive value or serum lipid profiles on the basis of gender and hypermetabolism in patients with ALS.
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