Sleep Disturbances in Alzheimer Disease Tied to Loss of ‘Wakeful’ Neuron
Researchers sought to examine the association between the number of important subcortical wake-promoting neurons and clinical sleep phenotypes in patients with AD or PSP.
Researchers sought to examine the association between the number of important subcortical wake-promoting neurons and clinical sleep phenotypes in patients with AD or PSP.
Male mice were exposed to chronic stress using a social defeat stress experiment. Mice were assessed for behavioral deviations and impacts to motor learning after the stress experiment as well as neural changes due to stress.
In a close vote, an advisory panel for the US Food and Drug Administration decided not to recommend the approval of an experimental drug for amyotrophic lateral sclerosis (ALS).
AMX0035 is an oral, fixed-dose coformulation of sodium phenylbutyrate and taurursodiol, also known as ursodoxicoltaurine.
Researchers sought to determine the effect GBA variants have on cognitive status in patients with amyotrophic lateral sclerosis.
In a retrospective analysis, researchers assessed the effect of statin therapy on the incidence of Alzheimer disease and other age-related neurodegenerative diseases (NDD), and whether its effect on NND risk varies among molecules, sex, or age groups.
Researchers sought to assess the incidence of spinal cord gray matter atrophy in patients with post-polio syndrome and its associations with muscle strength and functional decline.
Smoking is associated with higher odds of being diagnosed with multiple sclerosis (MS), and high alcohol intake is associated with retinal features indicative of more severe neurodegeneration in individuals with MS.
Researchers sought to investigate the association between serum asymmetric dimethylarginine (ADMA) levels and the progression and prognosis of amyotrophic lateral sclerosis, and to compare cerebrospinal fluid and serum ADMA levels with other ALS biomarkers.
In a retrospective study, researchers assessed the predictive value or serum lipid profiles on the basis of gender and hypermetabolism in patients with ALS.