Study Investigating Acthar Gel in the Treatment of ALS Discontinued
Mallinckrodt has permanently discontinued the phase 2b PENNANT trial investigating Acthar Gel (repository corticotrophin) for the treatment of amyotrophic lateral sclerosis.
Neurodegenerative Diseases
Significant Motor Cortex Degeneration in ALS According to MRS Findings
Study utilizing metabolic markers and magnetic resonance imaging finds cerebral degeneration is more pronounced in the motor cortex compared with the prefrontal cortex in patients with ALS.
Cognitive Decline Associated With Successive Amyloid-Beta and Tau Changes
Older adults with an increase in amyloid-β plaques followed by increased tau neurofibrillary tangles have shown lower cognition after 7 years.
Circulating Cholesterol Levels and Early-Onset AD: Is There a Link?
Study showed an association between early-onset Alzheimer disease and higher levels of low-density lipoprotein cholesterol independent of the effects of APOE, as well as demonstrated enrichment of rare coding variants of APOB.
How Virtual Reality Can Aid in Early Diagnosis of Alzheimer Disease
An entorhinal cortex-based virtual reality navigation task can differentiate patients with mild cognitive impairment at low and high risk for developing dementia.
Plasma Tau Levels Associated With Survival Time in Sporadic Creutzfeldt-Jakob Disease
The total tau concentration measured in either CSF or blood is strongly associated with survival time in sporadic Creutzfeldt-Jakob disease.
Characteristic Brain Lesions in Childhood Cerebral Adrenoleukodystrophy
A study describes early lesion development in asymptomatic boys with childhood cerebral ALD.
Longitudinal Cerebrospinal Fluid Biomarker Trajectories in Alzheimer Disease
Total tau and phosphorylated tau follow a different pattern of change in Alzheimer disease.
More Individuals at Risk for Polyglutamine Disease Than Previously Thought
Results indicated a considerably higher prevalence of carriers of intermediate and pathological ranges of polyglutamine disease–associated alleles among the general population than previously estimated.
African-Americans With ALS Survive Longer Than Caucasians
For people with ALS, African-Americans have longer survival than Caucasians when death is the outcome, but not when the outcome is death or tracheostomy and invasive ventilation.
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