Longitudinal Cerebrospinal Fluid Biomarker Trajectories in Alzheimer’s Disease
Total tau and phosphorylated tau follow a different pattern of change in Alzheimer’s disease.
Neurodegenerative Diseases
More Individuals at Risk for Polyglutamine Disease Than Previously Thought
Results indicated a considerably higher prevalence of carriers of intermediate and pathological ranges of polyglutamine disease–associated alleles among the general population than previously estimated.
African-Americans With ALS Survive Longer Than Caucasians
For people with ALS, African-Americans have longer survival than Caucasians when death is the outcome, but not when the outcome is death or tracheostomy and invasive ventilation.
Low-Dose Naproxen Does Not Reduce Progress of Presymptomatic Alzheimer Disease
Low-dose naproxen increases frequency of adverse health effects and does not reduce progression of presymptomatic Alzheimer disease in cognitively intact persons at risk.
Verubecestat, Atabecestat Not Beneficial for Preventing Alzheimer Disease
Use of the orally administered β-site amyloid precursor protein-cleaving enzyme 1 inhibitors, verubecestat and atabecestat, does not prevent clinical progression to Alzheimer disease.
Shorter Reproductive Span May Increase Dementia Risk in Women
Having a shorter reproductive span is associated with an increased risk for dementia in women.
Resident-to-Resident Aggression in Patients With Dementia
Gerontologists, practicing ethicists, policymakers, and health practitioners should consider the structural conditions of long-term care that both foster aggression and constrain prevention efforts, according to this commentary.
Ocular Protein Levels May Be Useful for Alzheimer DiseaseTesting
Patients with poor cognitive function have significantly lower levels of Alzheimer disease-related biomarkers in the vitreous humor.
Identifying Predictors of Suicidal Behavior in Huntington Disease
Researchers sought to identify variables that were associated with suicidal ideation or behavior in patients with Huntington disease.
Memantine Monotherapy Associated With Lower CV Events in Alzheimer Disease vs Other Anti-Dementia Drugs/Combination Therapy
Memantine monotherapy was associated with a 7% lower risk for any cardiovascular event compared with both acetylcholinesterase inhibitor monotherapy and combination therapy, according to a new study.
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