FDA Clears Hand-Held Vagus Nerve Stimulator for Migraine Prevention
The FDA has approved an expanded indication for the gammaCore device to include prevention of migraine.
Pain Management
Significant Reduction in Monthly Migraine Days Observed With Rimegepant in Prevention Trial
Biohaven announced positive topline results from a pivotal phase 2/3 study evaluating rimegepant for the preventive treatment of episodic and chronic migraine in adults.
Migraine and Headache Treatments
Adult doses for migraine and headache treatments including barbiturates, ergot alkaloids, and NSAIDs.
FDA Issues Statement Regarding NSAID Use and COVID-19
The Food and Drug Administration has issued a statement regarding the use of nonsteroidal anti-inflammatory drugs in patients with coronavirus disease 2019.
Rimegepant Orally Disintegrating Tablet Now Available for Acute Treatment of Migraine
Biohaven announced that rimegepant is now available for the acute treatment of migraine with or without aura in adults.
Intranasal Ketamine Reduces Pain in Children Hospitalized for Migraine
A single-center study showed that intranasal ketamine effectively reduced pain in children with migraine from hospital admission to discharge.
Differences in Adverse Events in Phase 2 and Phase 3 Studies: The Case of Lasmiditan
Phase 2 clinical trials investigating lasmiditan reported higher incidence and severity of TEAEs, compared with the phase 3 studies.
Galcanezumab Is Relatively Safe for Up to 1 Year in Patients With Episodic and Chronic Migraine
Treatment with humanized monoclonal antibody galcanezumab for up to 1 year was safe and tolerable for episodic and chronic migraine prophylaxis.
Computer-Adaptive Tests Offers Feasible Assessment of Patient-Reported Outcomes in Low Back Pain
The Patient-Reported Outcomes Measurement Information System (PROMIS) assessing physical function and pain interference with computer adaptive tests offers a streamlined, effective approach for measuring self-reported outcomes in patients with chronic low back pain.
Opioid-Related Unintentional Deaths and Suicides Have Increased Since 2000
Between 2000 and 2017, unintentional deaths and suicides related to opioid use have increased substantially, whereas overall deaths from suicide have decreased.
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