FDA Rejects NDA for Sublingual Film Formulation of Apomorphine
In the Complete Response Letter, the FDA noted that it was unable to approve the application in its present form, however the Agency did not request additional clinical studies.
Parkinson’s Disease
Electrode Placement in Subthalamic Nucleus May Restore Nonmotor Cognitive Functioning
Investigators examined whether subthalamic nucleus during the use of deep brain stimulation has an effect on risk-reward trade-off decisions, and evaluated its dependency on electrode placement.
Sleep and Circadian Alterations in Parkinson’s: Understanding the Source for Smarter Treatment
Sleep alterations often precede cognitive and motor symptoms in PD and appear during the prodromal phase of the disease.
Improving Sleep Quality in Parkinson’s: Is Levodopa-Carbidopa Intestinal Gel Effective?
Further prospective masked studies with larger number of patients on levodopa-carbidopa intestinal gel (LCIG) infusion therapy are necessary to clarify the positive influence of LCIG on sleep quality in patients with advanced Parkinson disease.
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