FDA Issues Complete Response Letter for Libervant
Libervant is a buccally administered soluble film of diazepam used to treat acute uncontrolled seizures in patients with refractory epilepsy on stable AED regimens.
Seizure Disorders
Generalized Epilepsy Tied to Higher Sleep Apnea Risk
Patients with generalized epilepsy have a higher risk for OSA and treatment of OSA may be an important part of treatment of epilepsy.
Generalized Seizures and Other Predictors of Post-Ictal Headache in Patients With Epilepsy
In patients with epilepsy, post-ictal headaches are associated with drug-resistant epilepsy, generalized seizures, and a family history of migraine.
FDA Requires Boxed Warning Update for Benzodiazepines
Benzodiazepines are widely used to treat a variety of conditions including anxiety disorders, insomnia and seizures.
Ketamine Infusions Effective as Super-Refractory Status Epilepticus Treatment
Ketamine infusion significantly decreased seizure burden within 24 hours in patients with super-refractory status epilepticus.
Specific Epileptiform Abnormalities are Linked to Seizures in Alzheimer Disease
Specific features of epileptiform abnormalities are associated with clinical seizures in Alzheimer disease, like right temporal hyperexcitability.
Increase in Epilepsy-Related Mortality Rates Was Partly Driven by Neurologic Factors
Increases in multiple neurologic factors likely led the increase in United States epilepsy-related mortality rates between 1999 and 2017.
Seizures During Menstrual Cycle Tied to Drug-Resistant Epilepsy
In women with genetic generalized epilepsy, having more frequent seizures during the menstrual cycle is associated with drug-resistant epilepsy.
History of Epilepsy Increases Pediatric Self-Injurious Behavior Risk
Children, adolescents, and young adults have greater risk of self-injurious behavior and suicide ideation if they have a childhood history of epilepsy.
Epidiolex Approved for Tuberous Sclerosis Complex-Associated Seizures
Epidiolex is a pharmaceutical formulation of highly purified cannabidiol.
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