Intrinsic Circadian Sleep-Wake Rhythm Disorders: Latest Guidance and Treatment
Melatonin and other melatonin receptor agonists have demonstrated efficacy in the treatment of circadian rhythm disorders in both pediatric and adult populations.
Melatonin and other melatonin receptor agonists have demonstrated efficacy in the treatment of circadian rhythm disorders in both pediatric and adult populations.
Digital CBT involved 6 weekly remote sessions via website or iOS app lasting approximately 20 minutes and comprised sleep restriction, stimulus control, relaxation techniques, cognitive therapy, and sleep hygiene and education.
Patients with bipolar disorder experienced significant reductions in sleep efficiency, which was not the case in patients with schizophrenia, although effect sizes for bipolar disorder were smaller overall.
Depression and anxiety were significantly associated with sleep difficulties, including trouble falling asleep, early waking, coughing or snoring, feeling too cold or too hot, and having a bad dream.
While carefully timed light exposure may address sleep problems associated with circadian rhythm disturbances, studies that examine light therapies in the context of sleep disorders have been largely lacking in measures of adherence and acceptability of these approaches.
Idorsia announced positive topline results from a phase 3 study of daridorexant, an investigational dual orexin receptor antagonist, for the treatment of insomnia.
Positive topline data from the phase 3 REST-ON trial evaluating FT218 (Avadel), an investigational, once-nightly formulation of sodium oxybate, showed that the treatment led to clinically meaningful improvement in patients with narcolepsy.
Researchers suggest the Narcolepsy Severity Scale be used more frequently in the clinical settings and future narcolepsy studies.
Children with congenital heart disease and comorbid obstructive sleep apnea are at increased risk for impaired neurocognition compared with children with congenital heart disease who do not have comorbid OSA.
As people around the world face prolonged periods of confinement to their homes during the COVID-19 pandemic, stress levels may disrupt sleep patterns and worsen overall mental health.