The Bidirectional Relationship of Sleep and Epilepsy: More Research Needed
While there has recently been a surge in research regarding the complex relationship between sleep and epilepsy, there still remain gaps in knowledge that must be addressed.
Sleep-Wake-Disorders
Intrinsic Circadian Sleep-Wake Rhythm Disorders: Latest Guidance and Treatment
Melatonin and other melatonin receptor agonists have demonstrated efficacy in the treatment of circadian rhythm disorders in both pediatric and adult populations.
Digital CBT Improves Insomnia, Anxiety, and Depression in Pregnant Women
Digital CBT involved 6 weekly remote sessions via website or iOS app lasting approximately 20 minutes and comprised sleep restriction, stimulus control, relaxation techniques, cognitive therapy, and sleep hygiene and education.
Schizophrenia and Bipolar Disorder May Share Sleep-Circadian Rhythm Phenotypes
Patients with bipolar disorder experienced significant reductions in sleep efficiency, which was not the case in patients with schizophrenia, although effect sizes for bipolar disorder were smaller overall.
Loneliness, Sleep Trouble May Raise Risk for Depression and Anxiety Among Adults With Intellectual Disabilities
Depression and anxiety were significantly associated with sleep difficulties, including trouble falling asleep, early waking, coughing or snoring, feeling too cold or too hot, and having a bad dream.
Light Therapies Feature Low Attrition and Relatively High Acceptance, Despite Research Drawbacks
While carefully timed light exposure may address sleep problems associated with circadian rhythm disturbances, studies that examine light therapies in the context of sleep disorders have been largely lacking in measures of adherence and acceptability of these approaches.
Daridorexant Improves Sleep, Daytime Performance in Phase 3 Insomnia Study
Idorsia announced positive topline results from a phase 3 study of daridorexant, an investigational dual orexin receptor antagonist, for the treatment of insomnia.
Clinical Improvement Observed in Narcolepsy Trial Evaluating Once-Nightly Sodium Oxybate Formulation
Positive topline data from the phase 3 REST-ON trial evaluating FT218 (Avadel), an investigational, once-nightly formulation of sodium oxybate, showed that the treatment led to clinically meaningful improvement in patients with narcolepsy.
The Narcolepsy Severity Scale Is Valid, Reliable in Treatment of Narcolepsy
Researchers suggest the Narcolepsy Severity Scale be used more frequently in the clinical settings and future narcolepsy studies.
Impaired Cognition in Children With OSA and Congenital Heart Disease
Children with congenital heart disease and comorbid obstructive sleep apnea are at increased risk for impaired neurocognition compared with children with congenital heart disease who do not have comorbid OSA.
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