Generic Name and Formulations:
Ticarcillin (as disodium) 3g, clavulanate (as potassium) 0.1g; IV inj; sodium content 4.75mEq/g of ticarcillin; potassium content 0.15mEq/g of Timentin.
Indications for TIMENTIN:
Susceptible bacterial septicemia (adults only), lower respiratory, bone and joint, skin and skin structure, urinary tract, gynecologic and intraabdominal infections.
By IV infusion over 30 minutes. >60kg: Systemic and UTI: 3.1g every 4–6 hours. Gynecologic: moderate: 200mg/kg/day of ticarcillin in divided doses every 6 hours; severe: 300mg/kg/day in divided doses every 4 hours. <60kg: 200–300mg/kg/day in divided doses every 4–6 hours. Renal impairment: reduce dose; see literature.
<3months: not recommended. Give by IV infusion over 30 minutes. ≥3months: (<60kg): mild-to-moderate infections: 200mg/kg per day of ticarcillin in equal divided doses every 6 hrs: severe infections: 300mg/kg per day of ticarcillin in equal divided doses every 4 hours. ≥3months (≥60kg): mild-to-moderate infections: 3.1g every 6 hrs; severe infections: 3.1g every 4 hours. Renal impairment: reduce dose; see literature.
Cephalosporin, imipenem or other allergy. Not for use in children for septicemia or H. influenzae type b infections. Heart disease. Sodium restricted diets. Monitor serum electrolytes (esp. potassium) and renal, hepatic, hematopoietic function during prolonged therapy. Discontinue if bleeding problems occur and treat. Pregnancy (Cat.B). Nursing mothers.
Antipseudomonal penicillin + β-lactamase inhibitor.
Probenecid increases ticarcillin levels. May cause false (+) Coomb's test.
Inj site reactions, rash, pruritus, drug fever, GI upset, blood dyscrasias, hemorrhage, hypokalemia, superinfection, anaphylaxis, CNS stimulation, elevated liver enzymes.
Neurology Advisor Articles
- Erenumab Superior to Placebo for Reducing Migraine Disability, Improving HRQoL
- Managing Status Epilepticus in Palliative Care: Accounting for Patient and Family Experience
- Congress Passes Bill to Fight Opioid Crisis
- Physical Activity Decreases Vascular Comorbidities in Multiple Sclerosis
- Review of Factors Impacting Sport-Related Concussion Headaches
- Anodal tDCS Offers Possible Benefit for Improving Item Recall in Post-Stroke Aphasia
- Hospitalization Tied to Brain Abnormalities in Older Adults
- Spending Often Persists in High-Cost Medicare-Medicaid Eligible
- Skills-Based Intervention Did Not Cut Systolic BP After Stroke, TIA
- High Frequency of Headaches Following Dialysis Associated With BUN and Blood Pressure