Survivors of childhood low-grade gliomas treated with radiotherapy have poorer neuropsychological and socioeconomic-status outcomes.
Computer-assisted diagnosis (CAD) can help physicians detect growth of low-grade gliomas.
AbbVie has halted enrollment in all ongoing studies of depatuxizumab mafodotin, after an Independent Data Monitoring Committee (IDMC) recommended a phase 3 study of the treatment be stopped due to a lack of survival benefit.
Highest incidence seen for patients with non-small cell lung cancer and triple-negative breast cancer
According to researchers, neovascularization is more common in glioblastoma, and extravasation is more common in primary CNS lymphoma.
This study involved the engineering of CAR-T cells specific for the EGFRvIII antigen to also secrete bispecific T cell engagers (BiTEs) against wild-type EGFR.
Neoadjuvant administration of programmed cell death protein 1 (PD-1) blockade seems to enhance local and systemic antitumor immune response in glioblastoma.
In certain parts of the analysis, the use of selective COX-2 inhibitors and metamizol was associated with inferior patient survival.
In preclinical models, the inhibition of phosphorylated STAT3 (p-STAT3) by WP1066 resulted in the direct attack of various tumor cells.
Standard therapy is more effective for female vs male patients with glioblastoma.