Seizure Disorders

Latest News

Phenytoin Oral Suspension Recalled Due to Potential for Inaccurate Dosing

Taro Pharmaceuticals announced the voluntary recall of 2 lots of Phenytoin Oral Suspension 125mg/mL packaged in 237mL bottles that may not resuspend properly when shaken, which can potentially result in under or overdosing.

FDA Accepts NDA for Diazepam Buccal Film for Management of Seizure Clusters

The Food and Drug Administration (FDA) has accepted for review the New Drug Application for Libervant® (diazepam; Aquestive Therapeutics) buccal film for the management of seizure clusters.

Supplemental NDA Submitted for Epidiolex for Tuberous Sclerosis Complex

Epidiolex is currently approved in the US to treat seizures associated with Lennox-Gastaut syndrome and Dravet syndrome.

Road Proximity Linked to Incidence of Neurologic Diseases

Road proximity is associated with an increased incidence of specific neurologic disorders.

Vigabatrin Approved for Younger Patients With Complex Partial Seizures

The FDA has expanded the approval of vigabatrin to include treatment of refractory complex partial seizures in patients aged 2 to <10 years of age.

Diazepam Nasal Spray Approved for Seizure Clusters

The FDA has approved Valtoco (diazepam nasal spray; Neurelis) for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity that are distinct from a patient’s usual seizure pattern in patients with epilepsy 6 years of age and older.

Lamotrigine Recalled Due to Cross-Contamination With Hypertension Medication

Taro Pharmaceuticals announced the voluntary recall of 1 lot of lamotrigine 100mg tablets to the consumer level due to cross-contamination with a small amount of enalapril maleate.

Novel Model Predicts Drug-Resistant Epilepsy in Children With Cerebral Palsy

Researchers established a prediction model based on the additive effect of 4 independent factors that form an accurate model for predicting the risk of drug-resistant epilepsy in children with cerebral palsy.

Antiepileptic Drug Exposure Low in Breastfeeding Infants

Among infants breastfed by mothers who are receiving drug therapy for epilepsy, antiepileptic drug (AED) concentrations in infant blood samples are substantially lower than those in maternal blood samples.

Patients Report Positive Ratings for Large-Scale Outpatient Tele-Epilepsy Program

This study described data collected from patients who self-selected to participate in the Cleveland Clinic Epilepsy Center’s virtual follow-up program.