Epilepsy Headline News | Epileptic Treatment Headlines

Currently, there are no pharmacological treatments that prevent SUDEP, and the only drugs associated with reduced SUDEP risk are antiepileptic agents.2 Therefore, patients should be counseled on the importance of complying with their antiseizure medications to reduce their risk of SUDEP. Because increased levels of various regulatory hormones and neurotransmitters following seizure activity have been associated with SUDEP, drugs that modify serotonin, adenosine, and other neurotransmitters might eventually be shown to prevent SUDEP, but research is ongoing.2

Use of Enzyme-Inducing Antiseizure Meds May Increase Long-Term CVD Risk

There appears to be a dose-dependent risk for incident cardiovascular disease associated with enzyme-inducing antiseizure medications.

depressed woman resting face on her fist

Psychiatric Comorbidities Tied to Higher Mortality in Epilepsy

Researchers assessed the impact of psychiatric morbidities on all-cause mortality in a cohort of adults with epilepsy admitted for video-electroencephalogram monitoring over two decades.

CBD Gel Effective for Seizure Reduction in Children With Encephalopathies

Researchers assessed the safety and tolerability of CBD transdermal gel in pediatric patients with developmental and epileptic encephalopathies, along with its effect on seizure frequency, sleep, and quality of life.

New Position Statement on MRI-Guided Laser Induced Thermotherapy for Epilepsy

The American Society for Stereotactic and Functional Neurosurgery provided a position statement on the use of MRI-guided laser interstitial thermal therapy, a selective ablation procedure, for various types of drug-resistant epilepsy.

Second-Line Home Therapy Outcomes in Patients With Status Epilepticus

In a tertiary analysis, researchers investigated the effects of receiving a second-line anticonvulsant medication that is part of a home regimen on outcomes of patients with refractory convulsive status epilepticus.

Case Study: Increasing Frequency of Nosebleeds Leads to Graves Disease Diagnosis

A 14-year-old adolescent with epilepsy presents with increasing episodes of nosebleeds, increased rate of speech, leg pain with little exercise, and irritable mood. Learn how delayed diagnosis of Graves disease affected her treatment.

Oxcarbazepine Tied to Nontrauma Fracture in Children Aged 4 to 13 With Epilepsy

For children aged 4 to 13 years with epilepsy, initiating oxcarbazepine, ASM is associated with an increased risk for nontrauma fracture.

No Evidence of Increased Suicidality With Common Antiseizure Drug Use

This meta-analysis aimed to evaluate whether there’s evidence that supports the FDA-mandated warning for increased suicidality risk with antiseizure drug usage among people with epilepsy.

Late-Onset Epilepsy Linked to Increased Risk for Death in Older Adults

Researchers explored the risk for death in late-onset epilepsy by analyzing data from the prospective Atherosclerosis Risk in Communities (ARIC) study.

Briviact Approval Expanded to Include Younger Patients with Partial-Onset Seizures

Briviact is now indicated for the treatment of partial-onset seizures in patients 1 month of age and older.

Eslicarbazepine Acetate Reduced Seizures in Adults With Treatment-Resistant Focal Epilepsy

Primary outcomes were a 50% or greater reduction in seizure frequency and the proportion of patients with complete cessation of seizures by trial conclusion.

Cannabis-Based Drug for Pediatric Epilepsy

Neurology advisor spoke with Charuta Joshi, MBBS regarding the use of the cannabis-based Epidiolex in the treatment of pediatric seizures.

If you prescribe opioids, inform your patients how to safeguard them. A locked cabinet or medicine safe box can ensure that only the patient has access. Should your patient no longer choose to use opioids, he or she can safely dispose of them through a drug take-back location, such as a local pharmacy or law enforcement.

Evidence to Support Suicidality Warning for Newer Antiseizure Meds Lacking

The analysis included 5 antiseizure medications (eslicarbazepine, perampanel, brivaracetam, cannabidiol, and cenobamate) evaluated in 17 randomized clinical trials.

The Role of the Gut-Brain Axis and S-equol in Epilepsy Treatment

A team of researchers sought to determine role of the gut-brain axis as a possible therapeutic target for Theiler murine encephalomyelitis (TMEV) linked seizures.

Molecular Diagnostics Reveal Novel Causal Lesions in Drug-Resistant Focal Epilepsy

Study researchers sought to assess how the diagnosis and understanding of focal epilepsy has improved with the inclusion of molecular genetic data in clinical decision making.

Targeted Therapy for Recurrent Seizure-Related GRIN1 Variant

This case study detailed a pediatric patient with drug-resistant seizures and early-onset epileptic encephalopathy who carried a GRIN1 variant.

Musicogenic Epilepsy and Antiglutamic Decarboxylase Antibodies: A Case Report

In this case report, a team of investigators highlighted findings in a 50-year-old woman who has been diagnosed with a seizure disorder for 14 years.

Language Development of Children of Women With Epilepsy Similar to Those of Healthy Women

Investigators compared 2-year-old children of women with epilepsy to those of healthy women to evaluate their cognitive abilities based on antiseizure medication exposure.

Epilepsy Seizures: 3 Summer Safety Tips to Share With Your Patients

As the weather gets warmer, people with epilepsy should be aware of the risks this brings for seizures. Some patients may be sensitive to heat, and some have suggested there are higher rates of epileptic seizures in warm weather. How can you educate your patients on how to be safe this summer?

Neonates With Acute Seizures May Be Overmedicated

Among neonates, there is no difference in functional neurodevelopment or epilepsy at 24 months for those discontinuing ASM before hospital discharge.

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