This statewide study assessed the risk of venous thromboembolism (VTE) in people with epilepsy (PWEs). Higher VTE risk in PWE than PWM suggests risk factors associated with epilepsy, independent of chronic neurologic illness. VTE occurrence in PWE is comparable to published rates among people with cancer.

Results

  • A total of 138,497 people with migraine (PWMs) and 67,900 PWEs (32,186 DE, 35,714 PE) were included.
  • VTE occurred in 2.7% of PWEs (4.2% among DE), and 0.6% of PWMs.
  • The hazard ratio for VTE in DE compared with PWMs was 3.08 (95% CI 2.76-3.42), adjusted for all covariables.
  • Higher numbers of comorbidities were strongly associated with VTE.
  • PWE had higher numbers of comorbidities (52% with 2+ comorbidities versus 23% of PWM), but the impact of comorbidities on VTE risk was larger in PWM.

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