Intranasal Midazolam Reduces Seizure Frequency

Treatment with in-MDZ reduced frequency of subsequent and generalized tonic-clonic seizure.

Lara Kay, of Philipps-University in Marburg, Germany, and colleagues evaluated the tolerability and efficacy of the ictal and immediate postictal application of intranasal midazolam (in-MDZ) in adolescents and adults during video–electroencephalography (EEG) monitoring.

Medical records of all patients treated with in-MDZ between 2008 and 2014 were reviewed retrospectively. For each single patient, the time span until recurrence of seizures was analyzed after an index seizure with and without in-MDZ application. To prevent potential bias, we defined the first seizure with application of in-MDZ as the in-MDZ index seizure. The control index seizure was the preceding, alternatively the next successive seizure without application of in-MDZ.

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