No Association Between Cardiovascular Drugs and Cognitive Impairment

HealthDay News — For older adults, there is no association between cardiovascular medication use and cognitive impairment, according to a study published in Cardiovascular Therapeutics.

Daniela Rohde, from the Royal College of Surgeons in Dublin, and colleagues examined the correlation between cardiovascular medication use and cognitive impairment in an analysis of 1903 participants (age 50 years and older) from wave 1 of the Irish Longitudinal Study on Ageing. The authors calculated cardiovascular medication use by using the proportion of days covered for antihypertensive, antithrombotic, and lipid-modifying medications.

The researchers found that there was no evidence of an independent correlation between impaired cognitive function and antihypertensive use (good adherence odds ratio [OR], 1.16 [95% CI, 0.88-1.52]; poor adherence OR, 1.39 [95% CI, 0.95-2.04]), antithrombotic use (good adherence OR, 1.26 [95 percent confidence interval, 0.93 to 1.7]; poor adherence odds ratio, 1.13 [95% CI, 0.8-1.59]), or lipid-modifying agent use (good adherence OR, 0.95 [95% CI, 0.71-1.25]; poor adherence OR, 0.88 [95% CI, 0.64-1.22]) after controlling for demographic and health variables.

“We found no evidence of an association between cardiovascular medication use and cognitive function,” the authors write. “Future studies should investigate the prospective associations between cognition and use of cardiovascular medications using longitudinal data.”

Disclosures: One author disclosed financial ties to the pharmaceutical industry.

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Rohde D, Hickey A, Williams D, Bennett K. Cognitive impairment and cardiovascular medication use: results from wave 1 of the Irish longitudinal study on ageing [published online August 24, 2017]. Cardiovasc Ther. doi:10.1111/1755-5922.12300