HealthDay News — The candidate viral entry receptor for Zika virus, AXL, is highly expressed by cells in the developing human cortex and retina, according to an experimental study published in Cell Stem Cell.
Tomasz J. Nowakowski, PhD, from the University of California in San Francisco, and colleagues explored the expression of receptors implicated in cell entry of several enveloped viruses including Zika virus across diverse cell types.
The researchers found that the candidate viral entry receptor AXL was highly expressed by human radial glial cells, astrocytes, endothelial cells, and microglia in the developing human cortex, based on single-cell RNA-seq and immunohistochemistry. High expression was also seen on progenitor cells in the developing retina. AXL expression in the radial glia was conserved in the cortex of developing mouse and ferret and in stem cell-derived cerebral organoids from humans.
Continue Reading
“The current manuscript constitutes an initial step toward the understanding of how Zika virus might cause developmental brain malformations,” the authors write.
You’ve read {{metering-count}} of {{metering-total}} articles this month.
We want you to take advantage of everything Neurology Advisor has to offer. To view unlimited content, log in or register for free.
{{login-button}} {{register-button}}
Want to view more content from Neurology Advisor?
Register now at no charge to access unlimited clinical news with personalized daily picks for you, full-length features, case studies, conference coverage, and more.
{{login-button}} {{register-button}}
Want to read more?
Please login or register first to view this content.