Magnesium sulfate is a more effective and fast-acting treatment of acute migraine headache than dexamethasone/metoclopramide, according to a study published in the Journal of Emergency Medicine.
Ali Shahrami, MD, of Shahid Beheshti University of Medical Sciences in Tehran, Iran, and colleagues, evaluated the efficacy of common migraine treatments in a group of 70 patients that were referred to an emergency department. The patients were divided into two equal treatment groups and were analyzed for pain severity at baseline using a numeric rating scale (8.2 vs. 8.0). Subsequent pain severity ratings were taken at 20 minutes, and 1- and 2-hour intervals.
The dexamethasone/metoclopramide treatment group showed statistically significant differences in pain severity between the baseline value and the 1- and 2-hour intervals (7.4 ± 1.4 [p = 0.36], 6.0 ± 2.4, and 2.5 ± 2.9 [p < 0.0001]). The magnesium sulfate group showed decreased pain severity across all three time intervals (5.2 ± 1.7, 2.3 ± 1.9, and 1.3 ± 0.66), with significant differences in pain severity compared to baseline and time intervals in the dexamethasone/metoclopramide group.
The researchers concluded that magnesium sulfate is a more effective and fast-acting treatment compared to dexamethasone/metoclopramide for the treatment of acute migraine headache.
This study addresses the controversy about the efficacy of currently used treatment modalities to alleviate acute migraine headaches.
Ali Shahrami, MD, of Shahid Beheshti University of Medical Sciences in Tehran, Iran, and colleagues, compared the effects of two common migraine treatments, magnesium sulfate and dexamethasone/metoclopramide, on patients suffering from acute migraine headache. 70 patients were split into two equal treatment groups, evaluating pain at baseline. The researchers found that magnesium sulfate was a faster-acting and more effective treatment than dexamethasone/metoclopramide for migraine.