Researchers assessed the effect of isradipine on clinical progression in previously untreated patients with early-stage PD.
In patients with Huntington disease, higher levels of functional impairment and current alcohol consumption were significantly correlated with missing work in multivariate logistic regression analyses.
Patients with Parkinson disease tend to have an increase in iron content with reduced perfusion in the substantia nigra.
Up to half of patients with Parkinson disease are also diagnosed with dementia, but tools to track changes in cognition are lacking.
A physically active lifestyle is associated with a reduced risk for Parkinson disease (PD).
Bladder training and conservative advice may improve lower urinary tract symptoms in patients with Parkinson disease.
There is a distinct genetic signature for young-onset Parkinson disease even in cells from those who have no known Parkinson disease-related mutations.
Compared with standard care alone, outpatient palliative care is associated with benefits among patients with Parkinson disease and related disorders.
A group of tardive dyskinesia experts has concluded that individuals taking antipsychotics should receive regular assessments, tardive dyskinesia may be indicated by mild movements isolated to 1 body area, an overall assessment of treatment is required for management, and thorough caregiver/patient discussions are required.
Responses to treatment depend on the target chosen, with 5 targets yielding positive outcomes, including the ventral anterior limb of the internal capsule, subthalamic nucleus, nucleus accumbens, ventral capsule/ventral striatum, or inferior thalamic peduncle, all involving fronto-striato-thalamocortical circuits.