CSF Biomarkers May Predict Dementia in Parkinson’s Disease

elderly man alone
elderly man alone
In people with PD, high neurofilament light chain protein, low Aβ1-42, and high heart fatty acid-binding protein was associate with PD dementia.

Alterations in cerebrospinal fluid (CSF) have been found in Parkinson’s disease (PD) and in PD dementia (PDD), but the prognostic importance of such changes is not well known. In vivo biomarkers for disease processes in PD are important for future development of disease-modifying therapies.

Researchers conducted a regional population-based, prospective cohort study of idiopathic parkinsonism that included patients diagnosed between January 1, 2004, and April 30, 2009, by a movement disorder team at a university hospital that represented the only neurology clinic in the region. 

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