Topological Efficiency Decreases in Parkinson’s Disease

Topological Efficiency Decreases in Parkinson's Disease
Topological Efficiency Decreases in Parkinson’s Disease
A resting-state fMRI study showed decreased topological efficiency in the cortico-basal ganglia motor circuit of patients with Parkinson's disease.

Parkinson’s disease is mainly characterized by dopamine depletion of the cortico-basal ganglia (CBG) motor circuit. Given that dopamine dysfunction could affect functional brain network efficiency, the present study utilized resting-state fMRI (rs-fMRI) and graph theoretical approach to study the topological efficiency changes of the CBG motor network in patients with mild to moderate Parkinson’s disease.

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