Topological Efficiency Decreases in Parkinson’s Disease

Parkinson’s disease is mainly characterized by dopamine depletion of the cortico-basal ganglia (CBG) motor circuit. Given that dopamine dysfunction could affect functional brain network efficiency, the present study utilized resting-state fMRI (rs-fMRI) and graph theoretical approach to study the topological efficiency changes of the CBG motor network in patients with mild to moderate Parkinson’s disease.

READ FULL ARTICLE From PLOS ONE