Multiple sclerosis (MS) is a complex neurologic disease caused by both genetic and environmental risk factors. To our knowledge, few studies have investigated the relationship between alcohol and MS risk, and these have been limited by small sample sizes and inconsistent results.

Hedström and colleagues reported that alcohol consumption exhibits a dose-dependent inverse association with MS risk. We aimed to determine whether individuals with alcohol misuse disorders, presumed to consume large quantities of alcohol, have a lower MS risk than the general population.

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