Ocrelizumab Beneficial for Relapse Risk and Disability in Multiple Sclerosis

Multiple Sclerosis
Multiple Sclerosis
Researchers sought to evaluate the safety and treatment outcomes of ocrelizumab, a humanized anti-CD20 immunoglobulin G antibody, in patients with multiple sclerosis.

Ocrelizumab, a humanized anti-CD20 immunoglobulin G (IgG) antibody, may effectively control the risk of relapse and disability worsening in patients with multiple sclerosis (MS), according to study results published in BMJ Neurology Open.

In 2017, after phase III trials, ocrelizumab was approved for treatment of relapsing forms of MS and primary progressive MS. However, in these ocrelizumab trials, patients who were aged 55 years and older were excluded, which meant the results may not be applicable to an older patient population. Also, concerns about risk of infection and other adverse events, commonly seen in this group, was not addressed.

The objective of the current study was to evaluate safety and treatment outcomes of ocrelizumab in a broader population of patients with MS.

Researchers analyzed a community-based MS population from the Providence Ocrelizumab Registry study. Eligible participants were aged 18 years and older and were diagnosed with relapsing MS, secondary progressive MS (SPMS), and PPMS.

Participants were prescribed ocrelizumab between March 28, 2017, and February 29, 2020. Ocrelizumab 600 mg was administered intravenously every 6 months in a hospital or clinic infusion center, and the first course included 2 infusions of ocrelizumab 300 mg 14 days apart.

A total of 355 patients were included (mean [SD] age, 51.8 [12.5] years; 71.9% female, 90.5% White); 78.3% had RMS, 13.2% had SPMS, and 8.5% had PPMS. The overall median disease duration was 12 years (interquartile range [IQR], 6.5-18.4).

Of the cohort, 228 patients (63.9%) had an infection, with upper respiratory infections occurring in 40.1% of participants and urinary tract infections in 33.1%. No difference was observed in the percentage of infections among patients younger than age 55 (68.5%, n=122) and those 55 or older (67.5%, n=104) (P =.94).

Among the participants, 63 hospitalizations occurred in 37 patients, with 24 hospitalizations resulting from infection. A total of 43 patients (12.1%) discontinued ocrelizumab, and 4 patients have died.

Logistic regression analyses demonstrated no evidence of a higher risk of infection occurring in patients with low IgG or immunoglobulin M levels.

The annualized relapse rate for patients with RMS who received ≥2 ocrelizumab courses was 0.09, compared with 0.34 in the 24 months before starting ocrelizumab. Among the 332 patients who had at least 2 courses of ocrelizumab, 33 relapsed. Of the 291 patients who had post-ocrelizumab scans, 262 (90.0%) had stable magnetic resonance imaging (MRI) results. Enhancing lesions occurred in 4 (1.4%) patients.

The median baseline Expanded Disability Status Scale (IQR) score was 3.0 (2.0-4.0) for RMS, 6.5 (6.0-7.5) for SPMS, and 6.5 (6.0-7.0) for PPMS, and those scores were unchanged at 12 months.

The study authors noted that limitations of registries include the involvement of multiple clinicians, which could introduce variability in the timing, frequency, and results of the assessments. In addition, the timing and frequency of MRI are typically less than ideal in community-based cohorts, and the lack of a blinded examiner may have introduced bias in the clinical outcome assessment.

“We believe that this study provides valuable information concerning the use of ocrelizumab in a large community-based MS center, and may assist in future decision-making regarding the selection and management of patients who are potential candidates for ocrelizumab therapy,” the researchers concluded.

Disclosure: Some of the study authors declared affiliations with pharmaceutical companies. Please see the original reference for a full list of authors’ disclosures.


Smoot K, Chen C, Stuchiner T, et al. Clinical outcomes of patients with multiple sclerosis treated with ocrelizumab in a US community MS center: an observational study. BMJ Neurol Open. Published online July 7, 2021. doi: 10.1136/bmjno-2020-000108