Sodium’s Affect on Multiple Sclerosis Influenced by Genetics, Sex

Myelin Repair
Myelin Repair
The effect of sodium levels on MS development is linked to genetics and gender.

Multiple sclerosis (MS) is a debilitating autoimmune neuroinflammatory disease influenced by genetics and the environment. MS incidence in female subjects has approximately tripled in the last century, suggesting a sex-specific environmental influence.

Recent animal and human studies have implicated dietary sodium as a risk factor in MS, whereby high sodium augmented the generation of T helper (Th) 17 cells and exacerbated experimental autoimmune encephalomyelitis (EAE), the principal model of MS. However, whether dietary sodium interacts with sex or genetics remains unknown.

Here, we show that high dietary sodium exacerbates EAE in a strain- and sex-specific fashion.

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