Neurobehavioral Disorders

Latest News

Spravato Approved for MDD With Acute Suicidal Ideation or Behavior

The approval was based on the ASPIRE I and II trials that compared the efficacy and safety of esketamine, an N-methyl-D-aspartate receptor antagonist, to placebo in 449 adults with moderate to severe MDD who had active suicidal ideation and intent.

Botox Injections May Ease Depression

Botox injections, which are commonly used to lessen wrinkles, migraines, muscle spasms, excessive sweating, and incontinence, may also help treat depression.

Feasibility of Treating Adolescents With First Episode Psychosis Using Antipsychotic Medication or Psychological Intervention

Adverse events, including voluntary psychiatric admission, suicide attempt, serious violent incident, voluntary admission to a general medical ward, overdose of medication or painkillers, were highest among the combined group compared to the monotherapies.

Long-Acting Injectable Antipsychotics May Delay Time to First Hospitalization in Early-Phase Schizophrenia

Compared with usual treatment, the use of long-acting injectable antipsychotics significantly increased the time to first hospitalization in patients with early-phase schizophrenia.

Depression, Anxiety May Be Signs That COVID-19 Is Attacking Brain

Depression and anxiety exhibited in coronavirus disease 2019 patients may be a sign that the virus impacts the central nervous system.

Polygenic Risk Scores Predict Progression to Other Disorders in Unipolar Depression

Polygenic risk scores predict the progression from unipolar depression to bipolar or psychiatric disorders.

Aspirin Does Not Prevent Late Life Depression, Despite Link to Inflammation

Depression has been linked to elevated markers of inflammation, and aspirin, a nonsteroid, anti-inflammatory medication, can irreversibly inhibit cyclooxygenase-1 and 2.

Higher Relapse Risk For Depression Between Childhood and Adolescence

Children who receive a depression diagnosis in their primary school age have a substantially higher risk of a depression relapse during adolescence compared with children who did not receive a depression diagnosis during their primary school age.

ENIGMA Study Finds Age Related Cortical Differences in ADHD, ASD, and OCD

Despite being common and often comorbid neurodevelopmental disorders, the study found robust yet subtle differences across age groups and the disorders in terms of cortical and subcortical brain structures.

Replicating Neuroimaging Abnormalities in Major Depression

Convergent abnormalities were observed in secondary analyses across portions of the amygdala, hippocampus, subgenual cingulate cortex, and putamen.