Weakened Brain Network Connectivity Observed in ADHD

brain mri
brain mri
Children with ADHD had weaker connections between the salience, default mode, and central executive networks.

Connections between 3 networks in the brain that play a crucial role in attention are weaker in children with attention-deficit hyperactivity disorder (ADHD).

Vinod Menon, PhD, a psychiatry professor at Stanford University School of Medicine, and colleagues used function MRI (fMRI) to examine brain scans of 180 children, half of whom had ADHD. In addition, they were assessed for symptoms of ADHD using standard diagnostic measures.

Each scan was rated based on the level of synchronization between the salience network and 2 other networks: the default mode and central executive. The former is responsible for directing activities such as daydreaming, while the latter interacts with information in working memory.

Dr Menon and his team hypothesized that poor coordination between the 3 regions could be responsible for mental conditions including autism, depression, and schizophrenia.

Children with ADHD had weaker connections between the 3 networks than children without the condition, the researchers reported in the journal Biological Psychiatry. The difference was large enough that brain scans could distinguish between those who had ADHD from those who did not.

In addition, children that had the weakest connections performed poorest on tests measuring inattentiveness.

Additional research is needed to determine whether fMRIs can also differentiate between the brains of children with ADHD and those with other neurodevelopmental conditions.


Cai W, Chen T, Szegletes L, Supekar K, Menon V. Aberrant Cross-Brain Network Interaction in Children With Attention-Deficit/Hyperactivity Disorder and Its Relation to Attention Deficits: A Multisite and Cross-Site Replication Study. Biol Psychiatry. 2015; doi:10.1016/j.biopsych.2015.10.017.

This article originally appeared on Psychiatry Advisor