Neurocognitive Disorders

Latest News

Recent Stressful Life Events Linked to Later Verbal Memory Decline

Middle-aged women, but not men, with a greater number of recent stressful life events have memory decline later in life.

COPD-Related Cognitive Impairment Unlike Other Forms of Dementia

The prevalence of cognitive impairment is higher in patients with COPD compared with healthy individuals.

Umibecestat Alzheimer Disease Prevention Trials Discontinued

Two pivotal phase 2/3 studies investigating umibecestat (CNP520) for the prevention of Alzheimer disease have been discontinued due to worsening in some measures of cognitive function. 

Estradiol May Protect Against Cognitive Impairment Mediated by Visceral Adiposity

Estradiol has anti-inflammatory properties and can strengthen the hypothalamic-pituitary-adrenal axis, which may oppose the effects of visceral adiposity.

Nilvadipine Increases Hippocampal Cerebral Blood Flow in Alzheimer Disease

Blood pressure reduction with nilvadipine resulted in an increase in hippocampal cerebral blood flow while global flow remained stable.

Family History of Dementia Tied to Early Memory Deficits

A first-degree family history of dementia is associated with memory deficits decades before the typical onset of Alzheimer disease.

Cognitive Decline Accelerates After Incident Coronary Heart Disease

Accelerated cognitive decline is associated with incident coronary heart disease after, but not before or immediately following, ischemic events.

Incident A-Fib Linked to Increased Dementia Risk

Incident atrial fibrillation (AF) is associated with increased dementia risk in elderly populations.

Dementia Tied to Anticholinergic Use

In a prospective study, the odds of dementia increased nearly 50% with daily use of anticholinergics for 3 years at the minimum effective dose recommended for older adults.

Alzheimer Disease Markers Predict Subsequent Decline in Mild Cognitive Impairment

Age and Alzheimer disease biomarkers are associated with decline in patients with mild cognitive impairment who initially reverted to normal cognition.