Middle-aged women, but not men, with a greater number of recent stressful life events have memory decline later in life.
The prevalence of cognitive impairment is higher in patients with COPD compared with healthy individuals.
Two pivotal phase 2/3 studies investigating umibecestat (CNP520) for the prevention of Alzheimer disease have been discontinued due to worsening in some measures of cognitive function.
Estradiol has anti-inflammatory properties and can strengthen the hypothalamic-pituitary-adrenal axis, which may oppose the effects of visceral adiposity.
Blood pressure reduction with nilvadipine resulted in an increase in hippocampal cerebral blood flow while global flow remained stable.
A first-degree family history of dementia is associated with memory deficits decades before the typical onset of Alzheimer disease.
Accelerated cognitive decline is associated with incident coronary heart disease after, but not before or immediately following, ischemic events.
Incident atrial fibrillation (AF) is associated with increased dementia risk in elderly populations.
In a prospective study, the odds of dementia increased nearly 50% with daily use of anticholinergics for 3 years at the minimum effective dose recommended for older adults.
Age and Alzheimer disease biomarkers are associated with decline in patients with mild cognitive impairment who initially reverted to normal cognition.