People with depression or bipolar disorder often feel their thinking ability has gotten “fuzzy,” or less sharp than before their symptoms began. Now, researchers have shown in a very large study that effect is indeed real — and rooted in brain activity differences that show up on advanced brain scans.

What’s more, the results add to the mounting evidence that these conditions both fall on a spectrum of mood disorders, rather than being completely unrelated. That could transform the way doctors and patients think about, diagnose and treat them.

This article originally appeared on Psychiatry Advisor

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