In research settings, including patients with neurodegenerative diseases presents challenges regarding consent, communication, and ability to participate that must be addressed in order to avoid evidence-biased care.
Researchers sought to identify candidate casual genes for Parkinson disease by integrating the genome-wide association study results with large-scale expression quantitative trait loci in 13 brain tissues.
Researchers compared the performance of brain amyloid-beta (Aβ)42/40 measured using 8 different Aβ assays to detect abnormal brain Aβ status in patients with early Alzheimer disease.
Using MRI, researchers assessed cortical, subcortical, and cerebellar grey matter atrophy in patients with frontotemporal lobar degeneration disorders, including motor neuron disease, with known genetic mutations.
Researchers sought to investigate clinical predictors of the effect of subthalamic nucleus-deep brain stimulation on impulsive and compulsive behaviors in patients with Parkinson disease.
For patients with Alzheimer disease (AD), levetiracetam is well tolerated and improves performance on certain cognitive tasks among those with epileptiform activity.
Physicians may miss factors associated with pulmonary embolism, or fail to use these factors in making medical decisions, in patients who have dementia.
