Neurodegenerative Diseases

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Brain Aging and Dysregulated Protein Phosphorylation in Alzheimer Disease

Altered phosphorylation patterns of some proteins may have implications for sporadic Alzheimer disease.

Tau Positron Emission Tomography Better Predicts Cognitive Decline Among Patients With Alzheimer Disease

The researchers sought to understand the prognostic value of tau positron emission tomography for predicting cognitive decline across the clinical spectrum of Alzheimer disease.

Stem Cell Therapy Gets Fast Track Status for Parkinson Disease

DA01 is an investigational pluripotent stem cell-derived dopaminergic neuron therapy designed to replace the midbrian dopaminergic neurons lost in Parkinson disease.

Relapse Risk for Psychosis in Dementia Lower With Continued Pimavanserin

For patients with dementia-related psychosis who have a response to pimavanserin, the risk for relapse is lower with continuation of the drug versus discontinuation

Review Explores Risk for Early-Onset Stroke, Parkinson Disease With Methamphetamine Use

The review authors sought to elucidate the neurological harms of methamphetamine, which are well-documented but poorly understood.

Global Prevalence of Young-Onset Dementia Examined

The overall global age-standardized prevalence of young-onset dementia, in which symptoms start before age 65 years, is 119.0 per 100,000 population.

Solriamfetol May Improve Sleep Latency Among Patients With Parkinson Disease

This phase 2, double-blind trial of solriamfetol evaluated the dose-dependent effects on sleep latency in patients with Parkinson disease.

Two Major Health Systems Will Not Administer Controversial Aduhelm

Individual doctors can prescribe Aduhelm, but patients would have to go elsewhere to receive the drug via infusion

First Alzheimer Disease Prevention Trial Using Amyloid-Targeting Drugs Gantenerumab or Solanezumab

The researchers conducted a randomized, placebo-controlled, multi-arm trial of gantenerumab or solanezumab in participants with dominantly inherited Alzheimer disease across asymptomatic and symptomatic disease stages.

Outside-In vs Inside-Out Paradigms in Patients with Multiple Sclerosis

Study researchers examined the different paradigms on the pathophysiology of MS, the outside-in and the inside-out theories.