Neurodegenerative Diseases

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Clues to Memory Impairment in Cerebral Amyloid Angiopathy

The researchers’ objective was to assess the neuroimaging features of patients with cerebral amyloid angiopathy, or CAA, with and without objective memory impairment using tau PET imaging.

Machine-Learning Model Reliably Rates Resting Tremor and Bradykinesia in PD

A team of investigators sought to develop and study the feasibility of a machine learning-based automated rating for the 2 cardinal symptoms of Parkinson disease: resting tremor and bradykinesia.

Novel, Rare Variants Associated With Alzheimer Disease and Replicated in an Independent Cohort

The study researchers used deep whole-genome sequencing (WGS) to search for novel AD variants in 2247 individuals from 605 multiplex AD families from the National Institute on Mental Health and the National Institute on Aging (NIA) Alzheimer’s Disease Sequencing Project `data sets.

Subtype of Parkinson Disease Correlated With Local Gyrification Index

Researchers sought to identify cortical gyrification and white matter microstructural changes in patients with Parkinson disease with akinetic-rigid and tremor-dominant subtypes.

Apolipoprotein E4, Physical Activity Interact to Delay Cognitive Decline in PD

This study was motivated by observational data that linked physical activity with reduced risk for Parkinson disease and a reduction in cognitive decline progression.

The PD-PCS: A New Approach to Classifying Pain in Patients With Parkinson Disease

Researchers developed a framework to differentiate PD- from non-PD-related pain and classify PD-related pain into 3 groups — nociceptive, neuropathic, or nociplastic.

Younger Age at Type 2 Diabetes Onset Linked to Subsequent Dementia Risk

Younger age at onset of type 2 diabetes is associated with an increased risk for subsequent dementia later in life.

Nelotanserin May Be Ineffective for Motor, Vocal Manifestations of RBD in Lewy Body and PD Dementia

Using systematic video analysis, researchers assessed the efficacy of nelotanserin for symptomatic treatment of REM sleep behavior disorder in patients with dementia.

Parkinsonism Treatments

Parkinson’s drug treatment chart categorized by pharmacological class.

Gene Therapy Fast Tracked for APOE4 Associated Alzheimer Disease

The investigational adeno-associated virus mediated gene therapy is being developed to deliver the protective APOE2 gene to the CNS.