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CSF α-Synuclein Decreases Early in Drug-Naive Patients With Parkinson Disease

Cerebrospinal fluid (CSF) α-synuclein decreases early in untreated Parkinson disease (PD), yet α-synuclein does not appear to correlate with disease progression. This is according to a study in Movement Disorders. The ongoing, longitudinal study (Parkinson’s Progression Markers Initiative) included newly diagnosed, untreated patients with PD (n=423; mean age, 61.7 years) as well as age- and…

Amyotrophic Lateral Sclerosis Risk and the Role of Genetics

Inherited and noninherited genetic factors contribute equally to the risk for developing amyotrophic lateral sclerosis (ALS), and first-degree relatives of people with ALS tend to have a higher risk for the disease compared with the general population, even in the absence of known ALS-associated genetic mutations.
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