Neurodegenerative Diseases

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Persistent Midlife Loneliness May Up Later Dementia, AD Risk

Persistent loneliness in midlife is an independent risk factor for later dementia and Alzheimer disease.

People with Parkinson Disease Not Fully On Board With Cannabis

With cannabis in the United States becoming more widely available for medical and recreational use, some with Parkinson disease (PD) are trying cannabis to control symptoms. However, not that much is currently known about the attitudes and experiences regarding cannabis use among those with PD.

FDA Rejects Pimavanserin sNDA for Dementia-Related Psychosis

The sNDA submission was supported by data from the pivotal phase 3 HARMONY study.

African Americans More Likely to Carry Genetic Variants Associated With Dementia

Study researchers sought to assess the racial differences in triggering receptor expressed on myeloid cells 2 in patients with Alzheimer disease.

Metabolites in Sebum May Predict Parkinson Disease

With no conclusive preclinical diagnostic test for Parkinson disease, diagnosis is achieved primarily through observations by a physician of the decline in motor functions. And while studies of sebum are commonplace in dermatological conditions, sebum as a biofluid has rarely been used in disease diagnostics.

Exercise May Slow Cognitive Decline in Some With Early Parkinson Disease

Increased levels of physical activity may have a protective effect on apolipoprotein E ε4-related cognitive decline in early PD.

Dementia Diagnoses Higher Among Older US Adults with Schizophrenia

The researchers sought to estimate the age-specific incidence and prevalence of dementia diagnoses among older adults with schizophrenia in the United States compared to those without serious mental illness.

Risdiplam Shows Promise for Infants With Type 1 Spinal Muscular Atrophy

Investigators sought to examine the safety, pharmacokinetics, and pharmacodynamics of risdiplam in infants with type 1 spinal muscular atrophy.

Nondrug Interventions Can Help Alleviate Depression in Dementia Patients

For people with dementia with symptoms of depression, without a MDD, nondrug interventions are more efficacious than drug interventions.

Donanemab Studied in Early Symptomatic Alzheimer Disease

Donanemab, which targets a modified form of deposited amyloid-ß, results in slightly less cognitive and functional decline than placebo.