Amyloid Formation May Link Alzheimer’s and Type 2 Diabetes

Amyloid plaque
Amyloid plaque
Alzheimer's patients had 1.4 times higher concentrations of IAPP than non-Alzheimer's patients in temporal cortex.

The pathological process amyloidosis, in which misfolded proteins (amyloids) form insoluble fibril deposits, occurs in many diseases, including Alzheimer disease (AD) and type 2 diabetes mellitus (T2D). However, little is known about whether different forms of amyloid proteins interact or how amyloid formation begins in vivo.

A study published inThe American Journal of Pathology has found evidence that amyloid from the brain can stimulate the growth of fibrils in the murine pancreas and pancreatic-related amyloid can be found along with brain-related amyloid in human brain senile plaques.

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