ATXN2 Repeat Length May Determine ALS Risk

Much variation exists in association between ALS risk and ATXN2 CAG repeat alleles.

In this study, researchers analyzed the association between amyotrophic lateral sclerosis risk and spinocerebellar ataxia type 2 ATXN2 CAG repeat alleles in a review of nine studies. The association is complex and should be used as a framework to counsel individuals with long-normal ATXN2 repeats. 

Stefan M. Pulst, MD, of the department of neurology at the University of Utah, in Salt Lake City, and colleagues calculate association between ATXN2 CAG repeat alleles and increased risk of ALS across multiple ethnic groups.

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