Brain Insulin Resistance Biomarker May Aid in Alzheimer’s Diagnosis

A novel biomarker of brain insulin resistance defective in Alzheimer’s and detectable in blood shows promise for early preclinical diagnosis.

The protein, insulin receptor substrate-1 (IRS-1), plays a key role in insulin signaling in the brain. Brain insulin resistance occurs in AD even in the absence of peripheral insulin resistance, but until now, no brain biomarker of brain insulin resistance has been discovered.

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