Cholinesterase Inhibitors May Cause Dangerous Weight Loss in Dementia

Sick old woman
Sick old woman
A sudden, significant loss of weight can result in other adverse outcomes.

Meera Sheffrin, MD, of the University of California at San Francisco and San Francisco VA Medical Center, and colleagues conducted a retrospective cohort study from 2007 to 2010 to compare weight loss in people with dementia who were prescribed cholinesterase inhibitors and other medications.

Of 6,504 individuals that met study criteria, 1,188 started on cholinesterase inhibitors were matched to 2,189 started on other medications. The propensity-matched cohorts were well balanced on baseline covariates. Participants initiated on cholinesterase inhibitors had a higher risk of weight loss than matched controls at 12 months.

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