HealthDay News — The risk of dementia is increased for individuals with type 2 diabetes, with risk of vascular dementia increased in women, according to a meta-analysis published in Diabetes Care.

Saion Chatterjee, from Alfred Health in Melbourne, Australia, and colleagues conducted a meta-analysis to examine the sex-specific relationship between women and men with diabetes and incident dementia. Data were included from 14 studies, with 2,310,330 individuals and 102,174 dementia case patients.

The researchers found that diabetes correlated with an increased risk of any dementia in both sexes (women: pooled relative risk [RR], 1.62; men: pooled RR, 1.58), in multiple-adjusted analyses. For vascular dementia, the diabetes-associated RRs were 2.34 in women and 1.73 in men; the corresponding RRs were 1.53 and 1.49 for nonvascular dementia. Compared with men, women with diabetes had an increased risk for the development of vascular dementia (multiple-adjusted ratio of RRs, 1.19; P < 0.001).

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“Individuals with type 2 diabetes are at ~60% greater risk for the development of dementia compared with those without diabetes,” the authors write. “For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.”


Chatterjee S, Peters SAE, Woodward M, et al. Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia. Diabetes Care. 2015; doi:10.2337/dc15-1588.