Disruption of Iron Levels in the Brain Can Cause Cognitive Impairments

Topological Efficiency Decreases in Parkinson's Disease
Topological Efficiency Decreases in Parkinson’s Disease
Altered brain iron homeostasis can lead to adverse effects on brain functioning seen in neurodegenerative diseases.

In the CNS, iron in several proteins is involved in many important processes such as oxygen transportation, oxidative phosphorylation, myelin production and the synthesis and metabolism of neurotransmitters. Abnormal iron homoeostasis can induce cellular damage through hydroxyl radical production, which can cause the oxidation and modification of lipids, proteins, carbohydrates, and DNA.

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