HealthDay News — The combination of environmental enrichment (EE) and magnesium-L-threonate (MgT) is more effective than either treatment alone for improving cognition and spatial memory in a mouse model of Alzheimer’s disease (AD), according to a study published online in CNS Neuroscience & Therapeutics.
Ying Huang, from Tsinghua University in Beijing, and colleagues treated APP/PS1 mice with EE, MgT, or the combination of EE and MgT (EM), and compared the effect on memory function.
The researchers found that, compared with either treatment alone, EM was more effective in improving cognition and spatial memory in long-term (12 months; started at age 3 months, before disease manifestation) and short-term (3 months; started at age 6 months, after manifestation of disease) treatment.
The behavioral improvement corresponded with synaptic contact rescue in the AD mouse brain hippocampal region. EM rescued the activity reduction in 2 downstream molecules in the N-methyl-D-aspartate receptor (NMDAR) pathway (CaMKII and CREB), but neither single treatment did.
“Environmental enrichment and MgT may synergistically improve recognition and spatial memory by reducing synaptic loss and restoring the NMDAR signaling pathway in AD mice, which suggests that combination of EE and MgT may be a novel therapeutic strategy for AD,” the authors write.
Haung Y, Huang X, Zhang L, et al. Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer’s disease mice [published online November 10, 2017]. CNS Neurosci Ther. doi:10.1111/cns.12775